天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
3期
257-259
,共3页
癌,鳞状细胞%下咽%下咽肿瘤%免疫组织化学%AKT%ERK1/2
癌,鱗狀細胞%下嚥%下嚥腫瘤%免疫組織化學%AKT%ERK1/2
암,린상세포%하인%하인종류%면역조직화학%AKT%ERK1/2
carcinoma,squamous cell%hypopharynx%hypopharyngeal neoplasms%immunohistochemistry%AKT%ERK1/2
目的：探讨AKT和ERK1/2蛋白在下咽鳞状细胞癌组织及正常下咽黏膜组织中的表达。方法采用免疫组织化学SP法检测60例下咽鳞状细胞癌组织（鳞癌组）及15例正常下咽黏膜组织（对照组）中AKT和ERK1/2的表达情况，并分析2种蛋白与下咽癌临床和病理因素的关系及AKT与ERK1/2的相关关系。结果下咽鳞状细胞癌组织中AKT和ERK1/2的阳性表达率分别为78.3%(47/60)和66.7%(40/60)，明显高于正常下咽黏膜组织中的13.3%(2/15)和6.7%(1/15)，差异有统计学意义(P＜0.05)；组织分化程度越低，临床分期越晚，AKT和ERK1/2的阳性表达率越高，有淋巴结转移的癌组织中AKT和ERK1/2的阳性表达率较无淋巴结转移的癌组织高（P＜0.05或P＜0.01）。AKT和ERK1/2的表达呈正相关(rs=0.400，P＜0.05)。结论 AKT和ERK1/2在下咽鳞状细胞癌中均高度表达，两者共同促进下咽癌发生、发展和浸润转移。
目的：探討AKT和ERK1/2蛋白在下嚥鱗狀細胞癌組織及正常下嚥黏膜組織中的錶達。方法採用免疫組織化學SP法檢測60例下嚥鱗狀細胞癌組織（鱗癌組）及15例正常下嚥黏膜組織（對照組）中AKT和ERK1/2的錶達情況，併分析2種蛋白與下嚥癌臨床和病理因素的關繫及AKT與ERK1/2的相關關繫。結果下嚥鱗狀細胞癌組織中AKT和ERK1/2的暘性錶達率分彆為78.3%(47/60)和66.7%(40/60)，明顯高于正常下嚥黏膜組織中的13.3%(2/15)和6.7%(1/15)，差異有統計學意義(P＜0.05)；組織分化程度越低，臨床分期越晚，AKT和ERK1/2的暘性錶達率越高，有淋巴結轉移的癌組織中AKT和ERK1/2的暘性錶達率較無淋巴結轉移的癌組織高（P＜0.05或P＜0.01）。AKT和ERK1/2的錶達呈正相關(rs=0.400，P＜0.05)。結論 AKT和ERK1/2在下嚥鱗狀細胞癌中均高度錶達，兩者共同促進下嚥癌髮生、髮展和浸潤轉移。
목적：탐토AKT화ERK1/2단백재하인린상세포암조직급정상하인점막조직중적표체。방법채용면역조직화학SP법검측60례하인린상세포암조직（린암조）급15례정상하인점막조직（대조조）중AKT화ERK1/2적표체정황，병분석2충단백여하인암림상화병리인소적관계급AKT여ERK1/2적상관관계。결과하인린상세포암조직중AKT화ERK1/2적양성표체솔분별위78.3%(47/60)화66.7%(40/60)，명현고우정상하인점막조직중적13.3%(2/15)화6.7%(1/15)，차이유통계학의의(P＜0.05)；조직분화정도월저，림상분기월만，AKT화ERK1/2적양성표체솔월고，유림파결전이적암조직중AKT화ERK1/2적양성표체솔교무림파결전이적암조직고（P＜0.05혹P＜0.01）。AKT화ERK1/2적표체정정상관(rs=0.400，P＜0.05)。결론 AKT화ERK1/2재하인린상세포암중균고도표체，량자공동촉진하인암발생、발전화침윤전이。
Objective To investigate the expressions of AKT and ERK1/2 proteins in hypopharyngeal squamous cell carcinoma and normal hypopharyngeal mucosa. Methods The expressions of AKT and ERK1/2 proteins were exam-ined by immunohistochemical S-P technique in 60 patients with hypopharyngeal squamous cell carcinoma and 15 cases of normal hypopharyngeal mucosa . The relationship between expressions of AKT and ERK1/2 proteins and clinical pathologi-cal feathers was analyzed. Results The positive rates of the expressions of AKT and ERK1/2 were 78.3% (47/60) and 66.7%(40/60) in 60 cases of hypopharyngeal squamous cell carcinoma, which were significantly higher than those in 15 cas-es of normal hypopharyngeal mucosa [13.3%(2/15) and 6.7%(1/15), P<0.05]. The lower the degree of differentiation, the later the clinical stage, the higher the positive expression rates of AKT and ERK1/2. There were significantly higher expres-sions of AKT and ERK1/2 in patients with lymph node metastasis than those of patients without lymph node metastasis (P<0.05 or P<0.01). There was a positive correlation between expression levels of AKT and ERK1/2 (rs=0.400,P<0.05). Con-clusion There were higher expression levels of AKT and ERK1/2 in hypopharyngeal squamous cell carcinoma. The activa-tion of AKT and ERK1/2 proteins promotes hypopharyngeal occurrence, development and metastasis.
