CAJ | 학술논문

目的：探讨维吾尔药瘤果黑种草子对艾氏腹水瘤小鼠的抗癌及抗氧化作用。方法50只小鼠，随机分为正常组、模型组、瘤果黑种草子醇提组、瘤果黑种草子水提组、环磷酰胺（CY）组。观察小鼠抑瘤率、脾指数、胸腺指数和肝脏指数、艾氏腹水瘤瘤小鼠血清中的干扰素-γ（IFN-γ）、自然杀伤细胞（NK）、过氧化脂质（LPO）、超氧化物歧化酶（SOD）、丙二醛（MDA）含量的变化。结果瘤果黑种草子水提物不仅能提高 EAC 荷瘤小鼠的抑瘤率，且能增加血清中 IFN-γ、NK、SOD 的含量，降低血清中 LPO、MDA 的含量。结论维药瘤果黑种草子对小鼠具有明显的抗肿瘤及抗氧化作用。
목적：탐토유오이약류과흑충초자대애씨복수류소서적항암급항양화작용。방법50지소서，수궤분위정상조、모형조、류과흑충초자순제조、류과흑충초자수제조、배린선알（CY）조。관찰소서억류솔、비지수、흉선지수화간장지수、애씨복수류류소서혈청중적간우소-γ（IFN-γ）、자연살상세포（NK）、과양화지질（LPO）、초양화물기화매（SOD）、병이철（MDA）함량적변화。결과류과흑충초자수제물불부능제고 EAC 하류소서적억류솔，차능증가혈청중 IFN-γ、NK、SOD 적함량，강저혈청중 LPO、MDA 적함량。결론유약류과흑충초자대소서구유명현적항종류급항양화작용。
Objective To study effects of Uygur medicine fruit Nigella in Anti-tumor and anti-oxidation of transplanted EAC tumor mice.Methods 50 mice were randomly divided into five groups,the normal group,model group,tumor fruit Nigella sub-alcohol group,tumor fruit Nigella sub-water extraction group,cyclophosphamide (CY)group;and to determinate mouse tumor inhibition rate,spleen index, thymus index,liver index,IFN-γ,NK,LPO content change in EAC tumor-bearing mice serum.Results The Uygur medicine fruit Nigella can not only improve EAC inhibition rate of tumor-bearing mice;and can improve IFN-γ,NK,SOD and reduce LPO,MDA content in serum.Conclusion Uyghur medicine fruit Nigella have obvious effect in anti-tumor and anti-oxidation.