CAJ | 학술논문

目的：探讨血清淀粉样蛋白A（SAA）与类风湿关节炎（RA）疾病活动度的相关性及临床意义。方法收集44例RA患者、35例系统性红斑狼疮（SLE）患者、18例骨关节炎（OA）患者及30例正常对照者血清。采用酶联免疫吸附试验（ELISA）定量检测血清中SAA的浓度；魏氏法检测红细胞沉降率（ESR）；免疫比浊法检测C反应蛋白（CRP）的浓度。将血清SAA水平与疾病活动度评分（DAS28）及ESR、CRP等进行相关分析。结果 RA患者血清中SAA的水平均高于其他3组（P<0.05），血清ESR和CRP的浓度分别高于OA和正常对照组，与SLE组相比差异无统计学意义（P >0.05）。血清SAA水平分别与DAS28、ESR及CRP水平呈正相关，rs分别为0.790、0.674和0.679（均P<0.001）。结论 SAA可作为评估RA疾病活动度的新的血清学指标。
목적：탐토혈청정분양단백A（SAA）여류풍습관절염（RA）질병활동도적상관성급림상의의。방법수집44례RA환자、35례계통성홍반랑창（SLE）환자、18례골관절염（OA）환자급30례정상대조자혈청。채용매련면역흡부시험（ELISA）정량검측혈청중SAA적농도；위씨법검측홍세포침강솔（ESR）；면역비탁법검측C반응단백（CRP）적농도。장혈청SAA수평여질병활동도평분（DAS28）급ESR、CRP등진행상관분석。결과 RA환자혈청중SAA적수평균고우기타3조（P<0.05），혈청ESR화CRP적농도분별고우OA화정상대조조，여SLE조상비차이무통계학의의（P >0.05）。혈청SAA수평분별여DAS28、ESR급CRP수평정정상관，rs분별위0.790、0.674화0.679（균P<0.001）。결론 SAA가작위평고RA질병활동도적신적혈청학지표。
Objective To investigate the correlation between serum amyloid A (SAA) and disease activity (DAS28) in patients with rheumatoid arthritis (RA). Methods Forty-four patients with RA, 35 patients with systemic lupus erythe-matosus (SLE), 18 patients with osteoarthritis (OA) and 30 healthy controls (HC) were enrolled in this study. The levels of SAA were measured by ELISA. Erythrocyte sedimentation rate (ESR) was measured by the Westergren method. The value of serum C reactive protein (CRP) was examined by immunonephelometry assay. The correlation between SAA and DAS 28, ESR and CRP was assessed, respectively. Results The SAA levels were significantly higher in RA group than those of SLE, OA, and HC groups (P<0.05). The serum ESR and CRP levels were both higher in RA group than those of OA and HC groups (P>0.05), but there was no significant difference between RA group and SLE group. There was positive correlation between SAA and DAS28, ESR, and CRP levels (rs=0.790, P<0.001;rs=0.674, P<0.001;rs=0.679, P=0.004), respective-ly. Conclusion SAA may be a new serological marker to assess disease activity in RA.