CAJ | 학술논문

华法林是临床广泛使用的口服抗凝药物。由于自身狭窄的有效抗凝治疗范围以及个体间每日用药剂量的显著差异，困扰着许多患者和临床医生。近年来，许多研究均报道基因多态性是引起华法林个体间用药剂量差异的主要因素之一。部分学者建立基于药物基因组学的剂量方程，并在进行验证，评估其临床价值。本文综述了华法林相关药物基因组学的国内外最新进展，为进一步针对华法林的临床研究提供参考依据。
화법림시림상엄범사용적구복항응약물。유우자신협착적유효항응치료범위이급개체간매일용약제량적현저차이，곤우착허다환자화림상의생。근년래，허다연구균보도기인다태성시인기화법림개체간용약제량차이적주요인소지일。부분학자건립기우약물기인조학적제량방정，병재진행험증，평고기림상개치。본문종술료화법림상관약물기인조학적국내외최신진전，위진일보침대화법림적림상연구제공삼고의거。
Warfarin,a commonly prescribed anticoagulant,has warried lots of patients and doctors because of its narrow therapeutic range and large interindividual variability in daily dose.During recent years,many studies focus on genetic polymorphisms,regarding it as one of the main effects which lead to dose difference between individuals.Some of them established and verified pharmacogenetic-based warfarin-dosing algorithms and evaluated the clinical significance.Our review exhibits the latest development of warfarin-related pharmacogenomics home and abroad,in order to provide references for further clinical studies.