检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2014年
3期
266-269
,共4页
崔玲%刘云%金立钢%柏晓松
崔玲%劉雲%金立鋼%柏曉鬆
최령%류운%금립강%백효송
细菌感染%中性粒细胞%NEUT-X%NEUT-Y%CRP
細菌感染%中性粒細胞%NEUT-X%NEUT-Y%CRP
세균감염%중성립세포%NEUT-X%NEUT-Y%CRP
Bacterial infection%Neutrophil%NEUT-X%NEUT-Y%C-reactive protein
目的：探讨Sysmex XT-2000i全自动血液分析仪中性粒细胞NEUT-X和NEUT-Y参数对细菌感染诊断的临床意义。方法用Sysmex XT-2000i全自动血液分析仪检测114例细菌感染患者、96例细菌培养阴性组与142名健康体检者（正常对照组）血液样本，分析比较各组中性粒细胞参数NEUT-X、NEUT-Y、C反应蛋白（CRP）和毒性指数（TI）等结果。结果感染组中性粒细胞NEUT-X、NEUT-Y参数分别为1391．4±42．3、450．9±40．9，细菌培养阴性组分别为1344．5±37．0、422．7±45．9，正常对照组分别为1351．7±33．7、415．8±32．2，各组间差异均有统计学意义（P＜0．01）。NEUT-X、NEUT-Y参数与CRP和TI均具有较好的相关性。用于细菌感染诊断时，CRP诊断效能最高，其次为NEUT-X。当CRP、NEUT-X的临界值（Cut-off值）分别取20．5 mg/L、1370．5时，敏感性分别为94．7％、71．1％，特异性分别为71．4％、75．6％。结论感染性疾病患者NEUT-X和NEUT-Y参数明显升高，可作为感染性疾病诊断辅助指标之一。
目的：探討Sysmex XT-2000i全自動血液分析儀中性粒細胞NEUT-X和NEUT-Y參數對細菌感染診斷的臨床意義。方法用Sysmex XT-2000i全自動血液分析儀檢測114例細菌感染患者、96例細菌培養陰性組與142名健康體檢者（正常對照組）血液樣本，分析比較各組中性粒細胞參數NEUT-X、NEUT-Y、C反應蛋白（CRP）和毒性指數（TI）等結果。結果感染組中性粒細胞NEUT-X、NEUT-Y參數分彆為1391．4±42．3、450．9±40．9，細菌培養陰性組分彆為1344．5±37．0、422．7±45．9，正常對照組分彆為1351．7±33．7、415．8±32．2，各組間差異均有統計學意義（P＜0．01）。NEUT-X、NEUT-Y參數與CRP和TI均具有較好的相關性。用于細菌感染診斷時，CRP診斷效能最高，其次為NEUT-X。噹CRP、NEUT-X的臨界值（Cut-off值）分彆取20．5 mg/L、1370．5時，敏感性分彆為94．7％、71．1％，特異性分彆為71．4％、75．6％。結論感染性疾病患者NEUT-X和NEUT-Y參數明顯升高，可作為感染性疾病診斷輔助指標之一。
목적：탐토Sysmex XT-2000i전자동혈액분석의중성립세포NEUT-X화NEUT-Y삼수대세균감염진단적림상의의。방법용Sysmex XT-2000i전자동혈액분석의검측114례세균감염환자、96례세균배양음성조여142명건강체검자（정상대조조）혈액양본，분석비교각조중성립세포삼수NEUT-X、NEUT-Y、C반응단백（CRP）화독성지수（TI）등결과。결과감염조중성립세포NEUT-X、NEUT-Y삼수분별위1391．4±42．3、450．9±40．9，세균배양음성조분별위1344．5±37．0、422．7±45．9，정상대조조분별위1351．7±33．7、415．8±32．2，각조간차이균유통계학의의（P＜0．01）。NEUT-X、NEUT-Y삼수여CRP화TI균구유교호적상관성。용우세균감염진단시，CRP진단효능최고，기차위NEUT-X。당CRP、NEUT-X적림계치（Cut-off치）분별취20．5 mg/L、1370．5시，민감성분별위94．7％、71．1％，특이성분별위71．4％、75．6％。결론감염성질병환자NEUT-X화NEUT-Y삼수명현승고，가작위감염성질병진단보조지표지일。
Objective To investigate the clinical significance of Sysmex XT-2000i automatic hematology analyzer′s neutrophil parameter NEUT-X and NEUT-Y in the diagnosis of bacterial infection.Methods Blood samples were collected from 1 14 patients with bacterial infection,96 patients with bacterial culture negative and 142 healthy subjects (healthy control group)to detect and analyze NEUT-X,NEUT-Y,C-reactive protein (CRP)and toxity indices (TI). Results NEUT-X and NEUT-Y were 1 391.4 ±42.3 and 450.9 ±40.9 respectively in bacterial infection group,which were significantly higher than in bacterial culture negative group (1 344.5 ±37.0 and 422.7 ±45.9)and healthy control group(1 351.7 ±33.7 and 415.8 ±32.2)with statistical significance(P<0.01).NEUT-X and NEUT-Y were correlated with CRP and TI.For the diagnosis of bacterial infection,CRP had the best diagnosis efficacy,and NEUT-X had the secondary diagnosis efficacy.When the cut-off value of CRP and NEUT-X were 20.5 and 1 370.5,the sensitivities were 94.7% and 71.4%,and the specificities were 71.4% and 75.6%,respectively.Conclusions NEUT-X and NEUT-Y parameters increase significantly after bacterial infection.It can be used as assistant diagnosis parameters of bacterial infection.
