检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2014年
3期
254-257
,共4页
血管危险因子%内皮素-1%同型半胱氨酸%高敏C反应蛋白%颈动脉内膜中层厚度%高血压
血管危險因子%內皮素-1%同型半胱氨痠%高敏C反應蛋白%頸動脈內膜中層厚度%高血壓
혈관위험인자%내피소-1%동형반광안산%고민C반응단백%경동맥내막중층후도%고혈압
Vascular risk factor%Endothelin-1%Homocysteine%High-sensitivity C-reactive protein%Carotid artery intima-media thickness%Hypertension
目的:对不同血压水平的特定人群进行心血管危险因子进行检测,以探讨心血管风险因素检测在心血管疾病中的诊断价值和在心血管疾病预防中的价值。方法限定一定条件,根据“中国高血压防治指南2010”将246例实验对象分为正常血压组(35例)、正常血压高值组(46例)、高血压1级组(52例)、高血压2级组(55例)、高血压3级组(58例),分别测定5组血清内皮素-1(ET-1)、高敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平并用超声检测颈动脉内膜中层厚度(IMT),分析不同血压组间各项指标的差异。结果2级和3级高血压组Hcy水平高于其他3组(P<0.05);且3级高血压组高于2级高血压组(P<0.05)。3级高血压组hs-CRP水平高于其他4组(P<0.05);2级高血压组高于正常血压组、正常血压高值组(P<0.05);1级高血压组高于正常血压组(P<0.05)。1、2和3级高血压组ET-1水平明显高于正常血压组、正常血压高值组(P<0.05),且1、2和3级高血压各组间差异亦有统计学意义(P<0.05)。3级高血压组IMT高于其他4组(P<0.05),2级高血压组IMT高于正常血压组及正常血压高值组(P<0.05)。随着收缩压的升高,ET-1、hs-CRP、Hcy、IMT的检测值也逐渐升高[相关系数(r)分别为0.302、0.214、0.192、0.285,P均<0.05];ET-1、hs-CRP、Hcy与IMT呈明显正相关(r值分别为0.358、0.249、0.226,P均<0.05)。结论 ET-1、hs-CRP、Hcy水平及IMT与血压水平有很好的相关性。ET-1在反映血压变化中最为灵敏。为预防和延缓心血管危险事件的发生,应将 ET-1、hs-CRP、Hcy、IMT作为常规体检内容,特别是对于血压目前正常者。对于上述指标逐渐升高者更应引起注意。
目的:對不同血壓水平的特定人群進行心血管危險因子進行檢測,以探討心血管風險因素檢測在心血管疾病中的診斷價值和在心血管疾病預防中的價值。方法限定一定條件,根據“中國高血壓防治指南2010”將246例實驗對象分為正常血壓組(35例)、正常血壓高值組(46例)、高血壓1級組(52例)、高血壓2級組(55例)、高血壓3級組(58例),分彆測定5組血清內皮素-1(ET-1)、高敏C反應蛋白(hs-CRP)、同型半胱氨痠(Hcy)水平併用超聲檢測頸動脈內膜中層厚度(IMT),分析不同血壓組間各項指標的差異。結果2級和3級高血壓組Hcy水平高于其他3組(P<0.05);且3級高血壓組高于2級高血壓組(P<0.05)。3級高血壓組hs-CRP水平高于其他4組(P<0.05);2級高血壓組高于正常血壓組、正常血壓高值組(P<0.05);1級高血壓組高于正常血壓組(P<0.05)。1、2和3級高血壓組ET-1水平明顯高于正常血壓組、正常血壓高值組(P<0.05),且1、2和3級高血壓各組間差異亦有統計學意義(P<0.05)。3級高血壓組IMT高于其他4組(P<0.05),2級高血壓組IMT高于正常血壓組及正常血壓高值組(P<0.05)。隨著收縮壓的升高,ET-1、hs-CRP、Hcy、IMT的檢測值也逐漸升高[相關繫數(r)分彆為0.302、0.214、0.192、0.285,P均<0.05];ET-1、hs-CRP、Hcy與IMT呈明顯正相關(r值分彆為0.358、0.249、0.226,P均<0.05)。結論 ET-1、hs-CRP、Hcy水平及IMT與血壓水平有很好的相關性。ET-1在反映血壓變化中最為靈敏。為預防和延緩心血管危險事件的髮生,應將 ET-1、hs-CRP、Hcy、IMT作為常規體檢內容,特彆是對于血壓目前正常者。對于上述指標逐漸升高者更應引起註意。
목적:대불동혈압수평적특정인군진행심혈관위험인자진행검측,이탐토심혈관풍험인소검측재심혈관질병중적진단개치화재심혈관질병예방중적개치。방법한정일정조건,근거“중국고혈압방치지남2010”장246례실험대상분위정상혈압조(35례)、정상혈압고치조(46례)、고혈압1급조(52례)、고혈압2급조(55례)、고혈압3급조(58례),분별측정5조혈청내피소-1(ET-1)、고민C반응단백(hs-CRP)、동형반광안산(Hcy)수평병용초성검측경동맥내막중층후도(IMT),분석불동혈압조간각항지표적차이。결과2급화3급고혈압조Hcy수평고우기타3조(P<0.05);차3급고혈압조고우2급고혈압조(P<0.05)。3급고혈압조hs-CRP수평고우기타4조(P<0.05);2급고혈압조고우정상혈압조、정상혈압고치조(P<0.05);1급고혈압조고우정상혈압조(P<0.05)。1、2화3급고혈압조ET-1수평명현고우정상혈압조、정상혈압고치조(P<0.05),차1、2화3급고혈압각조간차이역유통계학의의(P<0.05)。3급고혈압조IMT고우기타4조(P<0.05),2급고혈압조IMT고우정상혈압조급정상혈압고치조(P<0.05)。수착수축압적승고,ET-1、hs-CRP、Hcy、IMT적검측치야축점승고[상관계수(r)분별위0.302、0.214、0.192、0.285,P균<0.05];ET-1、hs-CRP、Hcy여IMT정명현정상관(r치분별위0.358、0.249、0.226,P균<0.05)。결론 ET-1、hs-CRP、Hcy수평급IMT여혈압수평유흔호적상관성。ET-1재반영혈압변화중최위령민。위예방화연완심혈관위험사건적발생,응장 ET-1、hs-CRP、Hcy、IMT작위상규체검내용,특별시대우혈압목전정상자。대우상술지표축점승고자경응인기주의。
Objective To detect the vascular risk factors in the subjects with different blood pressure,in order to investigate the significance of vascular risk factors in the diagnosis and prevention of cardiovascular diseases.Methods A total of 246 subjects were classified into normal blood pressure group(35 cases),normal blood pressure high value group(46 cases),grade 1 hypertension group (52 cases),grade 2 hypertension group (55 cases)and grade 3 hypertension group(58 cases)according to the Guidelines for the Prevention and Treatment of Hypertension in China 2010.Serum endothelin-1 (ET-1),high-sensitivity C-reactive protein (hs-CRP)and homocysteine (Hcy)were determined,and the carotid artery intima-media thickness (IMT)was measured by color ultrasound.The difference among the groups was analyzed.Results The Hcy levels of grade 2 and 3 hypertension groups were higher than those of the other 3 groups (P<0.05 ),and the Hcy level of grade 3 hypertension group was higher than that of grade 2 hypertension group (P<0.05).The hs-CRP level of grade 3 hypertension group was higher than those of the other 4 groups (P<0.05),the hs-CRP level of grade 2 hypertension group was higher than those of normal blood pressure and normal blood pressure high value groups (P<0.05 ),and the hs-CRP level of grade 1 hypertension group was higher than that of normal blood pressure group (P<0.05 ).The ET-1 levels of grade 1 ,2 and 3 hypertension groups were higher than those of normal blood pressure and normal blood pressure high value groups (P<0.05 ),and the ET-1 levels of grade 1,2 and 3 hypertension groups were significant statistically(P<0.05).The IMT detection results of grade 3 hypertension group were higher than those of the other 4 groups(P<0.05),and those of grade 2 hypertension group were higher than those of normal blood pressure and normal blood pressure high value groups (P<0.05).ET-1, hs-CRP,Hcy and IMT increased with systolic pressure,and the correlation coefficients(r)were 0.302,0.214,0.192 and 0.285 (P<0.05);ET-1,hs-CRP and Hcy had positive correlations with IMT (r=0.358,0.249 and 0.226,P<0.05).Conclusions There are good correlations among ET-1,hs-CRP and Hcy with IMT and corresponding blood pressure,and the ET-1 is the most sensitive in the progress of blood pressure change.ET-1 ,hs-CRP,Hcy and IMT should be used as routine physical examination parameters in order to prevent or stop cardiovascular risk.Especially,the subjects with normal blood pressure at present should be paid attention.