CAJ | 학술논문

目的：探讨脑梗死采用阿托伐他汀联合肠溶阿司匹林预防复发的临床价值。方法选择我院2011年5月～2012年6月经由CT或MRI确诊并收治的脑梗死患者，合计169例。随机分为临床组85例和对照组84例。所有患者均实施神经内科常规治疗，常规组应用阿司匹林治疗，临床组在常规组基础上加用阿托伐他汀。而后比照两组治疗后的甘油三酯、总胆固醇及高、低密度脂蛋白水平，并统计脑梗复发情况。结果临床组其总胆固醇、甘油三酯及低密度脂蛋白水平均显著低于常规组（P＜0.05），其高密度脂蛋白水平显著高于常规组，差异有统计学意义（P＜0.01）。临床组85例在治疗期间3例脑梗复发、复发率为3.53%；常规组84例在治疗期间9例复发，复发率为10.71%。两组比较临床组其复发率显著低于常规组（P＜0.05），差异有统计学意义。结论脑梗死采用阿托伐他汀联合肠溶阿司匹林可有效改善患者血脂水平，遏制血栓形成，预防脑梗死复发。
목적：탐토뇌경사채용아탁벌타정연합장용아사필림예방복발적림상개치。방법선택아원2011년5월～2012년6월경유CT혹MRI학진병수치적뇌경사환자，합계169례。수궤분위림상조85례화대조조84례。소유환자균실시신경내과상규치료，상규조응용아사필림치료，림상조재상규조기출상가용아탁벌타정。이후비조량조치료후적감유삼지、총담고순급고、저밀도지단백수평，병통계뇌경복발정황。결과림상조기총담고순、감유삼지급저밀도지단백수평균현저저우상규조（P＜0.05），기고밀도지단백수평현저고우상규조，차이유통계학의의（P＜0.01）。림상조85례재치료기간3례뇌경복발、복발솔위3.53%；상규조84례재치료기간9례복발，복발솔위10.71%。량조비교림상조기복발솔현저저우상규조（P＜0.05），차이유통계학의의。결론뇌경사채용아탁벌타정연합장용아사필림가유효개선환자혈지수평，알제혈전형성，예방뇌경사복발。
Objective To explore the clinical value of atorvastatin combined with enteric-coated aspirin in the prevention of cerebral infarction recurrence. Methods 169 patients who were diagnosed with cerebral infarction by CT or MRI in our hospital from 2011 May to 2012 June were included and randomly divided into two groups with 85 cases in the clinical group and 84 cases in the control group. Neurological routine treatment was given to all patients. Besides that,enteric-coated aspirin was given to the control group while atorvastation and enteric-coated aspirin was given to the clinical group. The level of triglycerides, total cholesterol,and high and low density lipoprotein were compared between two groups after the treatment and recurrence of cerebral infarction was analyzed. Results The level of total cholesterol,triglycerides and low density lipoprotein in clinical group was lower than that in control group(P<0.05) while the high density lipoprotein level in clinical group was higher than that in control group (P<0.01). The difference was statistically significant. During the treatment,3 cases had cerebral infarction with a recurrence rate of 3.53% in clinical group while 9 cases had cerebral infarction with a recurrence rate of 10.71% in control group.Thus the recurrence rate in clinical group was significantly lower than that in control group with a statistically significant difference (P<0.05). Conclusion The application of atorvastation combined with enteric-coated aspirin can effectively improve the blood lipid in patients,inhibit thrombosis and prevent the recurrence of cerebral infarction.