CAJ | 학술논문

目的：探讨前列地尔联合疏血通治疗糖尿病下肢血管病变的临床疗效。方法：将糖尿病下肢血管病变120例随机分为2组，对照组应用前列地尔注射液10ug 加入生理盐水100ml滴壶中，静脉滴注；红花注射液20ml加入250 ml生理盐水中静脉滴注，每日1次。治疗组应用前列地尔注射液10ug 加入生理盐水100ml滴壶中，静脉滴注；疏血通注射液4ml加入250 ml生理静脉滴注；2组均以21天为1个疗程。观察2组治疗前后临床症状缓解情况及下肢踝肱指数（ABI）、双侧足背动脉血流量变化。结果：治疗组总有效率90．00％，对照组总有效率75．00％，2组总有效率比较差异有统计学意义（P＜0．05），治疗组疗效优于对照组。2组治疗后 ABI与本组治疗前比较差异均有统计学意义（P＜0．05），ABI、足背动脉血流量组间比较差异有统计学意义（P ＜0．05）。结论：前列地尔注射液联合疏血通治疗糖尿病下肢血管病变可提高 ABI值，改善足背动脉血流情况。
목적：탐토전렬지이연합소혈통치료당뇨병하지혈관병변적림상료효。방법：장당뇨병하지혈관병변120례수궤분위2조，대조조응용전렬지이주사액10ug 가입생리염수100ml적호중，정맥적주；홍화주사액20ml가입250 ml생리염수중정맥적주，매일1차。치료조응용전렬지이주사액10ug 가입생리염수100ml적호중，정맥적주；소혈통주사액4ml가입250 ml생리정맥적주；2조균이21천위1개료정。관찰2조치료전후림상증상완해정황급하지과굉지수（ABI）、쌍측족배동맥혈류량변화。결과：치료조총유효솔90．00％，대조조총유효솔75．00％，2조총유효솔비교차이유통계학의의（P＜0．05），치료조료효우우대조조。2조치료후 ABI여본조치료전비교차이균유통계학의의（P＜0．05），ABI、족배동맥혈류량조간비교차이유통계학의의（P ＜0．05）。결론：전렬지이주사액연합소혈통치료당뇨병하지혈관병변가제고 ABI치，개선족배동맥혈류정황。
Objective :To observe the therapeutic efect of combined use of alprostadil and Shu Xue Tong in the treatment of diabetic Diabetic Lower Extremity Vascular Disease .Methods:120 PDA patients were randomized to the treatment group (alprostadil+ Shu Xue Tong injection) and the con-trol group (alprostadil+ Hong Hua injection) and observed for 21days .Symptom relief ,ankle brachial index (ABI) of the lowerextremities and blood flow of pedal pulse before and after treatment were measured .Results :The total efective rate of treatment group was 90 .00% ,which was better than the control group(75 .00% )(P<0 .05) .There was significant diference between before and after treatment on the ABI ,blood flow of pedal pulse in two groups(P<0 .05) .the effect of treatment group is more obvious than that of the control group (P<0 .05) .Conclusion:Alprostadil Combined with Shu Xue Tong can effectively treat diabetic patients with lower extremity vascular lesions by expanding vascular diameteriof arteria dorsalis pedis ,raising blood flow of arteria dorsalis pedis and increasing ABI .