CAJ | 학술논문

目的：观察二冬汤对糖尿病前期的胰腺β细胞功能的影响。方法选择60例糖尿病前期患者作为观察对象，试验前进行葡萄糖耐量试验（ OGTT），检测项目包括血糖、C肽，并计算出β细胞功能角。给予二冬汤，每日1剂，连续口服2个月。试验结束时重复进行OGTT试验和上述检测项目，并计算出β细胞功能角。结果糖尿病前期治疗前空腹血糖（FPG）（6．83±0．25）mmol/L，C肽（4．17±0．09） ng/mL，餐后2 h血糖（2 hPG）（10．31±1．44）mmol/L，C肽（12．55±2．71） ng/mL；治疗后FPG（5．88±0．63）mmol/L，C肽（5．16±0．27） ng/mL，治疗后2 hPG（8．02±1．52） mmol/L，C肽（23．48±4．39） ng/mL。治疗前后FPG、C肽比较差异均有统计学意义（P＜0．05），治疗前后餐后2 hPG、C肽比较差异均有统计学意义（P＜0．01）。治疗前β细胞功能角为23°±1．35°，治疗后为58°±1．97°，治疗前后比较差异有统计学意义（P＜0．05）。结论二冬汤可以改善糖尿病前期患者胰岛功能，从而有效治疗糖尿病前期病变。
목적：관찰이동탕대당뇨병전기적이선β세포공능적영향。방법선택60례당뇨병전기환자작위관찰대상，시험전진행포도당내량시험（ OGTT），검측항목포괄혈당、C태，병계산출β세포공능각。급여이동탕，매일1제，련속구복2개월。시험결속시중복진행OGTT시험화상술검측항목，병계산출β세포공능각。결과당뇨병전기치료전공복혈당（FPG）（6．83±0．25）mmol/L，C태（4．17±0．09） ng/mL，찬후2 h혈당（2 hPG）（10．31±1．44）mmol/L，C태（12．55±2．71） ng/mL；치료후FPG（5．88±0．63）mmol/L，C태（5．16±0．27） ng/mL，치료후2 hPG（8．02±1．52） mmol/L，C태（23．48±4．39） ng/mL。치료전후FPG、C태비교차이균유통계학의의（P＜0．05），치료전후찬후2 hPG、C태비교차이균유통계학의의（P＜0．01）。치료전β세포공능각위23°±1．35°，치료후위58°±1．97°，치료전후비교차이유통계학의의（P＜0．05）。결론이동탕가이개선당뇨병전기환자이도공능，종이유효치료당뇨병전기병변。
Objective To investigate the effect of Erdong decoction on pancreaticβ-cell function in predia-betes patients .Methods 60 cases with prediabetic state were selected as object of observation .Before the experi-ment,the person were checked up OGTT ,test item include blood glucose ,serum C-peptide,and calculate the angle of beta cell function.After that,60 cases with prediabetic state take Erdong decoction once a day for two months .And they were repeated OGTT .Insulin sensibility was measured by improved insulin sensitivity index .Function of pancre-atic beta cell was expressed by the included angle of beta cell function .Results Prediabetic state fasting blood -glucose and serum C-peptide were 6.83 ±0.25 mmol/L and 4.17 ±0.09 ng/mL;2-hour postprandial blood glu-cose and serum C-peptide were 10.31 ±1.44 mmol/L and 12.55 ±2.71 ng/mL.After treatment prediabetic State fasting blood-glucose and serum C -peptide were 5.88 ±0.63 mmol/L and 5.16 ±0.27 ng/mL;2-hour postpran-dial blood glucose and serum C -peptide were 8.02 ±1.52 mmol/L and 23.48 ±4.39 ng/mL.Before and after treatment fasting glucose,C-peptide comparison was statistically significant ( P <0.05),before and after treatment 2h plasma glucose,C-peptide,the difference was significant ( P <0.01).Experimental group before and after treat-ment in included angle of beta cell function were 23°±1.35°and 58°±1.97°.There was a significant difference be-tween before and after treatment (P<0.01).Conclusion Erdong decoction can effectively treat precancerous le-sions of diabetic by improving islet function in patients with pre -diabetes .