CAJ | 학술논문

目的：研究原癌基因C- MYC在涎腺腺样囊性癌（SACC）中的表达及意义。方法应用免疫组化法对54例SACC和20例正常涎腺组织石蜡标本中C- MYC表达水平进行检测并比较。结果20例正常涎腺组织中C- MYC均呈阴性表达，54例SACC标本中C- MYC阳性表达43例，阳性率为79.6%，差异有统计学意义（P＜0.05）。有神经浸润、T4期C- MYC阳性率较无神经浸润、T1~3期高（P＜0.05），C- MYC的表达与年龄、性别、肿瘤部位、组织学类型、远处转移及淋巴结转移等生物学特性的差异均无统计学意义（均P＞0.05）。结论原癌基因C- MYC在SACC中高表达，与T分期及神经侵犯有关，有望成为SACC进展及预后的生物学标志之一。
목적：연구원암기인C- MYC재연선선양낭성암（SACC）중적표체급의의。방법응용면역조화법대54례SACC화20례정상연선조직석사표본중C- MYC표체수평진행검측병비교。결과20례정상연선조직중C- MYC균정음성표체，54례SACC표본중C- MYC양성표체43례，양성솔위79.6%，차이유통계학의의（P＜0.05）。유신경침윤、T4기C- MYC양성솔교무신경침윤、T1~3기고（P＜0.05），C- MYC적표체여년령、성별、종류부위、조직학류형、원처전이급림파결전이등생물학특성적차이균무통계학의의（균P＞0.05）。결론원암기인C- MYC재SACC중고표체，여T분기급신경침범유관，유망성위SACC진전급예후적생물학표지지일。
Objective To investigate the expression of C- MYC in salivary adenoid cystic carcinoma (SACC) and clinico-pathological significance. Methods Immunohistochemisty was used to determine tissue expression of C- MYC in 54 patients with salivary adenoid cystic carcinoma from Zhejiang Provincial Cancer Hospital and 20 samples of normal gland tissue. The clin-icopathological significance of C- MYC expression was analyzed. Results C- MYC was positively expressed in 43 of 54 SACC tissues and none of 20 normal salivary gland tissues with the positive rate was 79.6%and 0.0%, respectively (P<0.05). Further-more, C- MYC expression was higher in stage T4 and perineural invasion patients than those with state T1~3 and no perineural in-vasion patients(P<0.05). C- MYC expression was not correlated with age, gender, tumor location, lymph node metastasis, distant metastasis and histological type (P>0.05). Conclusion The expression of proto- oncogene C- MYC was correlated with T stag-ing and perineural invasion in SACC, incicating that it may be uses as a biological marker for SACC progress and prognosis.