CAJ | 학술논문

目的：探讨生脉注射液联合左卡尼汀对阿霉素相关心脏毒性反应的保护作用。方法将60例患者随机分为对照组和治疗组，对照组采用单纯化疗，治疗组在化疗同时加用生脉和左卡尼汀注射液。治疗前后检测心电图、心脏超声、cTnI。结果化疗后对照组与治疗组心电图异常率分别为53．33％和16．67％，差异有统计学意义（P＜0．05）；两组cTnI值分别为（0．394±0．054） ng/ml和（0．158±0．035） ng/ml，差异亦有统计学意义（ P＜0．05）。化疗后治疗组LVEF值略高于对照组，差异无统计学意义（P＞0．05）。结论生脉注射液联合左卡尼汀具有良好的预防和减轻阿霉素所致急性心脏毒性作用。
목적：탐토생맥주사액연합좌잡니정대아매소상관심장독성반응적보호작용。방법장60례환자수궤분위대조조화치료조，대조조채용단순화료，치료조재화료동시가용생맥화좌잡니정주사액。치료전후검측심전도、심장초성、cTnI。결과화료후대조조여치료조심전도이상솔분별위53．33％화16．67％，차이유통계학의의（P＜0．05）；량조cTnI치분별위（0．394±0．054） ng/ml화（0．158±0．035） ng/ml，차이역유통계학의의（ P＜0．05）。화료후치료조LVEF치략고우대조조，차이무통계학의의（P＞0．05）。결론생맥주사액연합좌잡니정구유량호적예방화감경아매소소치급성심장독성작용。
Objective To investigate the protective effect of Sheng Mai injection combined with Levocarnitine for adria -mycin-related cardiac toxicity .Methods 60 cases were randomly divided into the control group and the therapy group ,the control group were treated by chemotherapy ,the therapy group were treated by chemotherapy ,Sheng Mai injection and Levocarnitine .The electrocardiogram ,cardiac ultrasound and cTnI were detected before and after therapy .Results The abnormal rates of electrocar-diogram in the 2 groups were 53.33%and 16.67%,the difference had statistical significance (P<0.05).And the concentration of serum cTnI after therapy in the therapy group was significantly lower than that of the control group [(0.394 ±0.054)ng/ml vs (0.158 ±0.035)ng/ml,P<0.05].LVEF in the 2 groups after therapy had no statistical significance (P>0.05).Conclusion ShengMai injection and Levocarnitine could obviously prevent and reduce the acute cardiac toxicity reaction caused by adriamy -cin.