实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
3期
343-345
,共3页
申捷(单唾液酸四己糖神经节苷钠)%磁共振波谱成像%放射性脑损伤
申捷(單唾液痠四己糖神經節苷鈉)%磁共振波譜成像%放射性腦損傷
신첩(단타액산사기당신경절감납)%자공진파보성상%방사성뇌손상
Monosialotetrahexosylganglioside Sodium Injection%Magnetic resonance spectroscopy ( MRS)%Radiation en-cephalopathy
目的：探讨申捷在早期放射性脑损伤防治中的作用。方法将鼻咽癌患者随机分为两组，对照组采用放疗＋肾上腺皮质激素方案；治疗组采用放疗＋肾上腺皮质激素＋申捷方案。申捷每天100 mg，加入到生理盐水或5％葡萄糖水中静脉滴注。两组均于放疗前及放疗后2个月行颅脑MRI、MRS检查，，并测定NAA/Cr和Cho/Cr值。结果对照组放疗后双颞叶NAA/Cr明显下降（t＝2．389，P＝0．022），治疗组无明显下降（t＝0．065，P＝0．949）；而对照组Cho/Cr放疗后明显升高（t＝2．355，P＝0．031），治疗组无明显升高（t＝1．371，P＝0．178）。结论申捷在脑放射性损伤早期阶段有预防及治疗作用。
目的：探討申捷在早期放射性腦損傷防治中的作用。方法將鼻嚥癌患者隨機分為兩組，對照組採用放療＋腎上腺皮質激素方案；治療組採用放療＋腎上腺皮質激素＋申捷方案。申捷每天100 mg，加入到生理鹽水或5％葡萄糖水中靜脈滴註。兩組均于放療前及放療後2箇月行顱腦MRI、MRS檢查，，併測定NAA/Cr和Cho/Cr值。結果對照組放療後雙顳葉NAA/Cr明顯下降（t＝2．389，P＝0．022），治療組無明顯下降（t＝0．065，P＝0．949）；而對照組Cho/Cr放療後明顯升高（t＝2．355，P＝0．031），治療組無明顯升高（t＝1．371，P＝0．178）。結論申捷在腦放射性損傷早期階段有預防及治療作用。
목적：탐토신첩재조기방사성뇌손상방치중적작용。방법장비인암환자수궤분위량조，대조조채용방료＋신상선피질격소방안；치료조채용방료＋신상선피질격소＋신첩방안。신첩매천100 mg，가입도생리염수혹5％포도당수중정맥적주。량조균우방료전급방료후2개월행로뇌MRI、MRS검사，，병측정NAA/Cr화Cho/Cr치。결과대조조방료후쌍섭협NAA/Cr명현하강（t＝2．389，P＝0．022），치료조무명현하강（t＝0．065，P＝0．949）；이대조조Cho/Cr방료후명현승고（t＝2．355，P＝0．031），치료조무명현승고（t＝1．371，P＝0．178）。결론신첩재뇌방사성손상조기계단유예방급치료작용。
Objective To explore the preventive effect of Monosialotetrahexosylganglioside Sodium Injection on the radi -ation encephalopathy in the early stage .Methods 56 cases of nasopharyngeal carcinoma patients were divided into 2 groups:The control group were treated with radiotherapy and Dexamethasone Sodium Phosphate Injection ,the treatment group were teated with radiotherapy plus Dexamethasone Sodium Phosphate Injection and Monosialotetrahexosylganglioside Sodium Injection .The content of NAA,Cho,or Cr in brain tissue were detected by Magnetic resonance spectroscopy before radiotherapy and after 2 months.Results In the control group,NAA/Cr was lower after radiotherapy than before in brain parenchyma (t=2.389,P=0.022),Cho/Cr was higher after radiotherapy than before in brain parenchyma (t=2.355,P=0.031).In the treatment group, there's no significant difference in NAA/Cr(t=0.065,P=0.949) and Cho/Cr (t=1.371,P=0.178)before and after radiother-apy.Conclusion Monosialotetrahexosylganglioside Sodium Injection can prevent the occurrence of radiation encephalapathy in the early stage .
