CAJ | 학술논문

目的：探讨影响子宫内膜癌根治术后的生存因素。方法对126例子宫内膜癌Ⅰb～Ⅱa期根治术后生存10年患者的临床资料进行回顾性分析。应用Kaplan-Meier法计算累计生存率，各因素间比较采用卡方检验。并对各临床参数进行单因素和COX模型的多因素分析。结果3年以上生存率达92％（155/169），5年以上生存率达82％（139/169）、10年以上生存率达74％（126/169）。分析结果表明：影响生存率的主要因素是细胞学分级、肌层浸润、淋巴结转移、术后是否行辅助治疗（P＜0．05）；而肿瘤大体分型对生存率无显著影响（P＞0．05），术后放疗、化疗及孕激素治疗对患者生存率的影响无显著性差异（ P＞0．05）。结论早期发现、早期诊断是提高子宫内膜癌患者术后10年生存率的前提，早期手术治疗及术后辅助治疗是提高患者术后10年生存率的关键。
목적：탐토영향자궁내막암근치술후적생존인소。방법대126례자궁내막암Ⅰb～Ⅱa기근치술후생존10년환자적림상자료진행회고성분석。응용Kaplan-Meier법계산루계생존솔，각인소간비교채용잡방검험。병대각림상삼수진행단인소화COX모형적다인소분석。결과3년이상생존솔체92％（155/169），5년이상생존솔체82％（139/169）、10년이상생존솔체74％（126/169）。분석결과표명：영향생존솔적주요인소시세포학분급、기층침윤、림파결전이、술후시부행보조치료（P＜0．05）；이종류대체분형대생존솔무현저영향（P＞0．05），술후방료、화료급잉격소치료대환자생존솔적영향무현저성차이（ P＞0．05）。결론조기발현、조기진단시제고자궁내막암환자술후10년생존솔적전제，조기수술치료급술후보조치료시제고환자술후10년생존솔적관건。
Objective To study the survival factors of endometrial cancer after radical resection .Methods Retrospec-tive analysis of clinical data of 126 cases ofⅠb-Ⅱa endometrial cancer who underwent radical resection in 10 years.The cumula-tive survival rate was calculated by Kaplan-Meier method,the factors were compared with the chi-square test.Multiple factors a-nalysis and single factor and COX model in various clinical parameters .Results The 3 year survival rate was 92%(155/169), the 5 year survival rate was 82%(139/169),the 10 year survival rate was 74%(126/169).The results showed that the main factors affecting the survival rate were cytologic grading ,myometrial invasion,lymph node metastasis,postoperative therapy (P<0.05);and the tumor size had no significant effect on survival rate (P>0.05),Effect of postoperative radiotherapy ,chemothera-py and hormone on the survival rate had no significant difference (P>0.05).Conclusion Early detection,early diagnosis are the precondition to improve the survival rate of patients of endometrial cancer in 10 years,early operation and postoperative adju-vant therapy are the key to improve the postoperative 10-year survival rate .