CAJ | 학술논문

目的：探讨Livin与Smac/DIABLO蛋白在结直肠癌组织中的表达及其临床意义。方法应用免疫组织化学 SP法，检测100例结直肠癌组织和30例癌旁正常组织中Livin和Smac/DIABLO蛋白的表达情况。结果结直肠癌、癌旁正常组织中Livin 蛋白阳性表达率分别为64．0％（64/100）、16．7％（5/30），差异具有统计学意义（P＜0．05）；结直肠癌、癌旁正常组织中Smac/DIABLO蛋白阳性表达率分别为36．0％（36/100）、80．0％（24/30），差异具有统计学意义（P＜0．05）。两者表达与结直肠癌临床分期、肿瘤浸润深度及淋巴结转移密切相关，P＜0．05。Livin 与Smac/DIABLO 表达间呈显著负相关，γ＝-0．245，P＜0．05。结论 Livin 高表达及Smac/DIABLO 低表达或失活，可能在结直肠癌的发生发展中起重要作用。
목적：탐토Livin여Smac/DIABLO단백재결직장암조직중적표체급기림상의의。방법응용면역조직화학 SP법，검측100례결직장암조직화30례암방정상조직중Livin화Smac/DIABLO단백적표체정황。결과결직장암、암방정상조직중Livin 단백양성표체솔분별위64．0％（64/100）、16．7％（5/30），차이구유통계학의의（P＜0．05）；결직장암、암방정상조직중Smac/DIABLO단백양성표체솔분별위36．0％（36/100）、80．0％（24/30），차이구유통계학의의（P＜0．05）。량자표체여결직장암림상분기、종류침윤심도급림파결전이밀절상관，P＜0．05。Livin 여Smac/DIABLO 표체간정현저부상관，γ＝-0．245，P＜0．05。결론 Livin 고표체급Smac/DIABLO 저표체혹실활，가능재결직장암적발생발전중기중요작용。
Objective To investigate the expression and clinical significance of Livin and Smac /DIABLO in colorectal carcinoma .Methods Immunohistochemisty was used to detect the expressions of Livin and Smac /DIABLO in 100 colorectal car-cinoma tissues and 30 normal colorectal mucosal tissues .Results The positive expression rate of Livin in colorectal carcinoma tissues was significantly higher than that of the normal colorectal mucosal tissues (64.0%vs 16.7%,P<0.05),the positive ex-pression rate of Smac/DIABLO was significantly lower in colorectal carcinoma tissues than that of the normal colorectal mucosal tissues(36.0%vs 80.0%,P<0.05).The expressions of Livin and Smac/DIABLO were closely related with the clinical stage、depth of tumor invasion and lymph node metastases (P<0.05).The expressionsof Livin and Smac/DIABLO were negatively cor-related(γ=-0.245,P<0.05).Conclusion The over-expression of Livin and low-expression or inactivation of Smac/DIABLO protein may play an important role in the occurrence and development of colorectal carcinoma .