中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
5期
12-13
,共2页
氨基末端B型钠尿肽前体%超敏C反应蛋白%心肌肌钙蛋白I%慢性心力衰竭
氨基末耑B型鈉尿肽前體%超敏C反應蛋白%心肌肌鈣蛋白I%慢性心力衰竭
안기말단B형납뇨태전체%초민C반응단백%심기기개단백I%만성심력쇠갈
N-terminal pro-B-type natriuretic peptide%Cardiac Troponin I%High sensitive C-reactive protein%Chronic heart failure
目的：探讨血清氨基末端B型钠尿肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)和心肌肌钙蛋白I(cTnI)的联合检测在慢性心力衰竭(CHF)诊断中的临床意义。方法将100例CHF患者按美国纽约心脏病协会(NYHA)分级方案分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级，同时检测100例CHF患者和30例正常对照组NT-proBNP、hs-CRP和cTnI水平。结果CHF患者不同心功能分级组间血清NT-proBNP、hs-CRP和cTnI水平差异有统计学意义(P<0.05)，并且随着心力衰竭严重程度的加重而增高；NYHAⅠ级患者的血清NT-proBNP、hs-CRP检测水平与对照组比较差异有统计学意义(P<0.05)， cTnI检测水平差异无统计学意义(P>0.05)。结论NT-proBNP是诊断CHF较好的心肌标志物，联合检测血清NT-proBNP、hs-CRP和cTnI水平可为慢性心力衰竭(CHF)提供诊断依据，且其升高幅度与病情的严重性相一致。
目的：探討血清氨基末耑B型鈉尿肽前體(NT-proBNP)、超敏C反應蛋白(hs-CRP)和心肌肌鈣蛋白I(cTnI)的聯閤檢測在慢性心力衰竭(CHF)診斷中的臨床意義。方法將100例CHF患者按美國紐約心髒病協會(NYHA)分級方案分為Ⅰ、Ⅱ、Ⅲ、Ⅳ級，同時檢測100例CHF患者和30例正常對照組NT-proBNP、hs-CRP和cTnI水平。結果CHF患者不同心功能分級組間血清NT-proBNP、hs-CRP和cTnI水平差異有統計學意義(P<0.05)，併且隨著心力衰竭嚴重程度的加重而增高；NYHAⅠ級患者的血清NT-proBNP、hs-CRP檢測水平與對照組比較差異有統計學意義(P<0.05)， cTnI檢測水平差異無統計學意義(P>0.05)。結論NT-proBNP是診斷CHF較好的心肌標誌物，聯閤檢測血清NT-proBNP、hs-CRP和cTnI水平可為慢性心力衰竭(CHF)提供診斷依據，且其升高幅度與病情的嚴重性相一緻。
목적：탐토혈청안기말단B형납뇨태전체(NT-proBNP)、초민C반응단백(hs-CRP)화심기기개단백I(cTnI)적연합검측재만성심력쇠갈(CHF)진단중적림상의의。방법장100례CHF환자안미국뉴약심장병협회(NYHA)분급방안분위Ⅰ、Ⅱ、Ⅲ、Ⅳ급，동시검측100례CHF환자화30례정상대조조NT-proBNP、hs-CRP화cTnI수평。결과CHF환자불동심공능분급조간혈청NT-proBNP、hs-CRP화cTnI수평차이유통계학의의(P<0.05)，병차수착심력쇠갈엄중정도적가중이증고；NYHAⅠ급환자적혈청NT-proBNP、hs-CRP검측수평여대조조비교차이유통계학의의(P<0.05)， cTnI검측수평차이무통계학의의(P>0.05)。결론NT-proBNP시진단CHF교호적심기표지물，연합검측혈청NT-proBNP、hs-CRP화cTnI수평가위만성심력쇠갈(CHF)제공진단의거，차기승고폭도여병정적엄중성상일치。
Objective To explore the clinical significance of joint detection of serum N-terminal pro-B-type natriuretic peptide (BNP), high sensitive C-reactive protein(hs-CRP) and cardiac troponin I(cTnI) in the diagnosis of chronic heart failure(CHF). Methods According to the criteria of American New York Heart Association(NYHA), their heart functions of the 100 patients with CHF were classified into level I-IV, and select the healthy control group 30 subjects. The levels of serm NT-proBNP, hs-CRP and cTnI were detected and analyzed in the CHF group and the control group. Results Compared with the control group, the levels of NT-proBNP、hs-CRP in CHF NYHA I grade group were significantly higher(P<0.05), the level of cTnI was no significantly difference(P>0.05);The levels of NT-proBNP, hs-CRP and cTnI had statistical significance in different grades of CHF(P<0.05);The NYHA class was worse, and the levels of three indicators were significantly higher. Conclusion NT-proBNP is a good cardiac marker for the diagnosis of CHF, joint detection of serum NT-proBNP, hs-CRP and cTnI levels provide reference supporty in the early diagnosis of CHF.
