山西医药杂志
山西醫藥雜誌
산서의약잡지
SHANXI MEDICAL JOURNAL
2014年
5期
483-486
,共4页
张江菊%郑秀惠%郭建新%郑英如%李力
張江菊%鄭秀惠%郭建新%鄭英如%李力
장강국%정수혜%곽건신%정영여%리력
宫颈疾病%原位杂交 ,荧光%基因%端粒酶
宮頸疾病%原位雜交 ,熒光%基因%耑粒酶
궁경질병%원위잡교 ,형광%기인%단립매
Cervix diseases%In situ hybridization,fluorescence%Genes%Telomerase
目的:探讨应用荧光原位杂交(FISH)技术检测人类染色体端粒酶(hTERC)基因异常扩增在子宫颈病变中的临床意义。方法用FISH技术检测118例宫颈脱落细胞中 hTERC基因异常扩增情况。结果118例患者病理学诊断为炎症12例,宫颈上皮内瘤变(CIN )Ⅰ46例,CIN Ⅱ31例,CIN Ⅲ18例,浸润癌11例。FISH检测 hTERC基因异常扩增阳性率在炎症组为0,CINⅠ组19.6%(9/46),CINⅡ组51.6%(16/31),CINⅢ组77.8%(14/18),浸润癌组90.9%(10/11),各组间比较差异有统计学意义(P<0.01)。通过对未治疗的CINⅠ和CINⅡ患者共26例进行随访,发现hTERC基因扩增预测CINⅠ、CINⅡ病变进展的敏感性83.3%,预测病变维持或消退的特异性90.0%。结论hTERC基因的异常扩增随宫颈病变级别增高而增加,对宫颈病变的筛查有一定临床意义,检测 hTERC基因的异常扩增对宫颈早期病变进展有预测意义,可作为监测宫颈病变进展的生物遗传学指标。
目的:探討應用熒光原位雜交(FISH)技術檢測人類染色體耑粒酶(hTERC)基因異常擴增在子宮頸病變中的臨床意義。方法用FISH技術檢測118例宮頸脫落細胞中 hTERC基因異常擴增情況。結果118例患者病理學診斷為炎癥12例,宮頸上皮內瘤變(CIN )Ⅰ46例,CIN Ⅱ31例,CIN Ⅲ18例,浸潤癌11例。FISH檢測 hTERC基因異常擴增暘性率在炎癥組為0,CINⅠ組19.6%(9/46),CINⅡ組51.6%(16/31),CINⅢ組77.8%(14/18),浸潤癌組90.9%(10/11),各組間比較差異有統計學意義(P<0.01)。通過對未治療的CINⅠ和CINⅡ患者共26例進行隨訪,髮現hTERC基因擴增預測CINⅠ、CINⅡ病變進展的敏感性83.3%,預測病變維持或消退的特異性90.0%。結論hTERC基因的異常擴增隨宮頸病變級彆增高而增加,對宮頸病變的篩查有一定臨床意義,檢測 hTERC基因的異常擴增對宮頸早期病變進展有預測意義,可作為鑑測宮頸病變進展的生物遺傳學指標。
목적:탐토응용형광원위잡교(FISH)기술검측인류염색체단립매(hTERC)기인이상확증재자궁경병변중적림상의의。방법용FISH기술검측118례궁경탈락세포중 hTERC기인이상확증정황。결과118례환자병이학진단위염증12례,궁경상피내류변(CIN )Ⅰ46례,CIN Ⅱ31례,CIN Ⅲ18례,침윤암11례。FISH검측 hTERC기인이상확증양성솔재염증조위0,CINⅠ조19.6%(9/46),CINⅡ조51.6%(16/31),CINⅢ조77.8%(14/18),침윤암조90.9%(10/11),각조간비교차이유통계학의의(P<0.01)。통과대미치료적CINⅠ화CINⅡ환자공26례진행수방,발현hTERC기인확증예측CINⅠ、CINⅡ병변진전적민감성83.3%,예측병변유지혹소퇴적특이성90.0%。결론hTERC기인적이상확증수궁경병변급별증고이증가,대궁경병변적사사유일정림상의의,검측 hTERC기인적이상확증대궁경조기병변진전유예측의의,가작위감측궁경병변진전적생물유전학지표。
Objective To investigate the expression and clinical significance of abnormal human telomerase RNA gene component(hTERC) gene amplification tested by fluorescence in situ hybridization (FISH ) in cervical lesions .Methods Abnormal amplification of hTERC gene in exfoliated cells was detected by FISH in 118 pa-tients .The results were then compared with pathologic findings .Results Cervical biopsy revealed inflammation in 12 patients ,CINⅠ in 46 patients ,CINⅡ in 31 patients ,CINⅢ in 18 patients ,and infiltrating carcinoma in 11 patients .In the inflammation ,CIN Ⅰ ,CIN Ⅱ ,CIN Ⅲ and infiltrating carcinoma group , the positive rates of hTERC gene amplification were 0 ,19.6% (9/46) ,51.6% (16/31) ,77.8% (14/18) and 90.9% (10/11) respec-tively (P<0.01) .In 26 patients with untreated CIN Ⅰ and CIN Ⅱ ,the sensitivity of detection of hTERC gene amplification to predict lesion progression was 83.3% ,and the specificity was 90.0% .Conclusion Abnormal am-plification of hTERC gene increased with the increasing grade in cervical lesions .Detection of abnormal amplifica-tion of hTERC gene is of predictive significance for progression of CIN Ⅰ /Ⅱ ,so it can assist in screening cervical lesions and identifying CINⅠ /Ⅱ patients with a high progression risk .