CAJ | 학술논문

目的：通过检测急性肺栓塞（APE）患者溶栓前后血浆氨基末端脑钠肽前体（NT-ProBNP）、D-二聚体水平，探讨其变化特点及意义。方法60例疑似APE患者，其中经CT确诊并符合溶栓条件的APE患者40例设为实验组，经CT排除APE患者20例为对照组。测定两组治疗前及实验组溶栓治疗2周后血浆 NT-ProBNP 与D-二聚体水平并进行比较。结果 NT-proBNP检测对早期APE患者的诊断灵敏度为92．3％，特异度为65％；D-二聚体检测对早期APE患者的诊断的灵敏度为100％，特异度为70％；实验组溶栓前血浆NT-ProBNP与D-二聚体水平显著高于对照组，差异有统计学意义（P＜0．01）。结论血浆NT-ProBNP与D-二聚体对APE具有重要的临床意义，可为APE患者早期诊断及疗效观察提供依据。
목적：통과검측급성폐전새（APE）환자용전전후혈장안기말단뇌납태전체（NT-ProBNP）、D-이취체수평，탐토기변화특점급의의。방법60례의사APE환자，기중경CT학진병부합용전조건적APE환자40례설위실험조，경CT배제APE환자20례위대조조。측정량조치료전급실험조용전치료2주후혈장 NT-ProBNP 여D-이취체수평병진행비교。결과 NT-proBNP검측대조기APE환자적진단령민도위92．3％，특이도위65％；D-이취체검측대조기APE환자적진단적령민도위100％，특이도위70％；실험조용전전혈장NT-ProBNP여D-이취체수평현저고우대조조，차이유통계학의의（P＜0．01）。결론혈장NT-ProBNP여D-이취체대APE구유중요적림상의의，가위APE환자조기진단급료효관찰제공의거。
Objective To detect plasma amino-terminal pro-brain natriuretic peptide (NT-ProBNP) ,D-Dimer levels in the pa-tients with acute pulmonary embolism (APE) in order to investigate their change characteristics and significance .Methods Among 60 patients with suspected APE ,40 cases diagnosed by CT and meeting the thrombolytic condition were set as the experimental group and other 20 cases of excluded APE by CT as the control group .Plasma NT-ProBNP and D-dimer before treatment in the two groups and after 2-week thrombolytic therapy in the experimental thrombolysis were detected and compared .Results The diagnos-tic sensitivity of NT-ProBNP for early APE was 92 .3% and the specificity was 65% ,while the diagnostic sensitivity of D-dimer for early APE was 100% and the specificity was 70% ;the plasma NT-ProBNP and D-dimer levels before thrombolysis in the experi-mental group were significantly higher than those in the control group with statistical differences (P<0 .01) .Conclusion Plasma NT-ProBNP and D-dimer has important clinical significance for APE and can provide the basis for the early diagnosis and the cura-tive effect observation of the patients with APE .