CAJ | 학술논문

目的：探讨该院2010～2012年真菌感染的动态变化及耐药情况，指导临床合理使用抗真菌药物。方法回顾性调查分析2010～2012年该院真菌病原菌分布和药敏试验情况，用WHONET5．6统计软件进行分析。结果3年来该院真菌感染病原菌主要为白色假丝酵母菌。分离标本主要是痰液和血液，内科、普外科和中西医结合科是真菌检出较多科室。5种假丝酵母菌对两性霉素B敏感率高，伊曲康唑耐药率较高。结论医院真菌感染病原菌分布发生变迁且真菌的耐药率不断升高，应加强真菌感染的动态监测和研究，减少肿瘤患者真菌感染的发生。
목적：탐토해원2010～2012년진균감염적동태변화급내약정황，지도림상합리사용항진균약물。방법회고성조사분석2010～2012년해원진균병원균분포화약민시험정황，용WHONET5．6통계연건진행분석。결과3년래해원진균감염병원균주요위백색가사효모균。분리표본주요시담액화혈액，내과、보외과화중서의결합과시진균검출교다과실。5충가사효모균대량성매소B민감솔고，이곡강서내약솔교고。결론의원진균감염병원균분포발생변천차진균적내약솔불단승고，응가강진균감염적동태감측화연구，감소종류환자진균감염적발생。
Objective To investigate the dynamic changes and drug resistance of fungal infection in our hospital during 2010 -2012 for guiding the clinical reasonable use of anti-fungal drugs .Methods The related clinical data and the drug sensitivity tests re-sults of fungal infection in the hospitalized patients from 2010 to 2012 were retrospectively analyzed by the WHONET 5 .6 soft-ware .Results Candida albicans was the major pathogen causing candida infection for these 3 years .The isolated specimens were mainly sputum and blood .In the departments of internal medicine ,general surgery and integrated Chinese and Western medicine ,the number of detected candida were more than that of the other departments .Five kinds of candida showed high sensitivity to ampho-tericin B and high resistance to itraconazole .Conclusion The distribution of pathogens causing nosocomial fungal infection has changed and the drug resistance rate is continuously rising .Therefore the dynamic monitoring and the study of fungal infection should be strengthened for reducing the occurrence of fungal infection in the patients with tumor .