CAJ | 학술논문

目的：探讨胃癌相关抗原MG7-Ag对胃癌的诊断价值。方法检索Pubmed、Embase、ISI Web of Knowledge、中国知网、维普和万方等数据库，检索时间截止到2013年4月5日。QUADAS量表用于对纳入文献进行质量评估。Stata12和Meta-DiSc软件用于分析纳入文献的异质性检验和M eta分析。结果检索到610篇文章，7篇文献含4516例患者符合纳入标准。评估其灵敏度、特异度、阳性似然比、阴性似然比和曲线下面积分别为：0．72（95％ C I：0．68～0．76）、0．94（95％ C I：0．93～0．94）、6．09（95％ CI：3．36～11．07）、0．34（95％ CI：0．21～0．56）和0．8934。结论综合研究结果表明，MG7-Ag在诊断胃癌时灵敏度为0．72，比现用的诊断标志物癌胚抗原（CEA）、糖蛋白抗原CA50和糖蛋白抗原CA19-9灵敏度高；特异度达0．94，有很高的排除其他疾病的价值，可作为胃癌诊断的标志物。
목적：탐토위암상관항원MG7-Ag대위암적진단개치。방법검색Pubmed、Embase、ISI Web of Knowledge、중국지망、유보화만방등수거고，검색시간절지도2013년4월5일。QUADAS량표용우대납입문헌진행질량평고。Stata12화Meta-DiSc연건용우분석납입문헌적이질성검험화M eta분석。결과검색도610편문장，7편문헌함4516례환자부합납입표준。평고기령민도、특이도、양성사연비、음성사연비화곡선하면적분별위：0．72（95％ C I：0．68～0．76）、0．94（95％ C I：0．93～0．94）、6．09（95％ CI：3．36～11．07）、0．34（95％ CI：0．21～0．56）화0．8934。결론종합연구결과표명，MG7-Ag재진단위암시령민도위0．72，비현용적진단표지물암배항원（CEA）、당단백항원CA50화당단백항원CA19-9령민도고；특이도체0．94，유흔고적배제기타질병적개치，가작위위암진단적표지물。
Objective To explore the clinical diagnostic value of monoclonal gastric cancer 7 antigen(MG7-Ag) in gastric cancer through a meta-analysis .Methods The PubMed ,Embase ,ISI Web of Knowledge ,China National Knowledge Infrastructure (CNKI) ,Wanfang databases were retrieved from their establishment to April 5 ,2013 .The qualities of the included literatures were assessed by the QUADAS scale .The heterogeneity test and meta-analysis were conducted by the Stata12 and the Meta-DiSc soft-wares .Results 610 articles were retrieved from databases .7 articles containing 4 516 cases conformed with the included standard . The sensitivity of MG7-Ag in diagnosing gastric cancer was 0 .72(95% CI:0 .68 -0 .76) ,its specificity was 0 .94(95% CI:0 .93 -0 .94) ,the positive likelihood ratio was 6 .09(95% CI:3 .36-11 .07) ,the negative likelihood ratio was 0 .34 (95% CI:0 .21-0 .56) and the AUC was 0 .893 4 .Conclusion The comprehensive research results indicate that MG7-Ag has the sensitivity of 0 .72 for di-agnosing gastric cancer ,which is higher than that of currently used diagnostic markers such as carcino-embryonic antigen(CEA) , CA50 and CA19-9 ,which has the high value for excluding other diseases and can be used as a marker for diagnosing gastric cancer .