CAJ | 학술논문

目的：探讨血浆同型半胱氨酸（Hcy）、叶酸（FA）、维生素B12（VB12）水平在冠心病（CHD）及合并糖耐量异常（IGT）患者中的应用价值。方法按纳入标准筛选的试验者80例，分为单纯CHD组36例，CHD合并IGT组44例；健康对照者70例作为对照组。测定 Hcy、FA、VB12水平，对检测结果进行统计学分析。结果两组患者Hcy水平均高于对照组，差异有统计学意义（P＜0．05），单纯CHD组阳性率为94．4％，CHD合并IGT组阳性率为88．6％；FA水平均低于对照组，与Hcy水平呈负相关（P＜0．05）；3组VB12水平比较差异无统计学意义（P＞0．05），两组Hcy水平与VB12相关性分析无统计学意义（P＞0．05）。结论血浆Hcy 水平在CHD 及合并IGT 中非常高且与FA 呈负相关，动态检测其水平对CHD 及合并IGT 的预警和治疗具有重要意义。
목적：탐토혈장동형반광안산（Hcy）、협산（FA）、유생소B12（VB12）수평재관심병（CHD）급합병당내량이상（IGT）환자중적응용개치。방법안납입표준사선적시험자80례，분위단순CHD조36례，CHD합병IGT조44례；건강대조자70례작위대조조。측정 Hcy、FA、VB12수평，대검측결과진행통계학분석。결과량조환자Hcy수평균고우대조조，차이유통계학의의（P＜0．05），단순CHD조양성솔위94．4％，CHD합병IGT조양성솔위88．6％；FA수평균저우대조조，여Hcy수평정부상관（P＜0．05）；3조VB12수평비교차이무통계학의의（P＞0．05），량조Hcy수평여VB12상관성분석무통계학의의（P＞0．05）。결론혈장Hcy 수평재CHD 급합병IGT 중비상고차여FA 정부상관，동태검측기수평대CHD 급합병IGT 적예경화치료구유중요의의。
Objective To investigate the application value of the plasma homocysteine (Hcy) ,folic acid (FA) and vitamin B12 (VB12 ) levels in the patients with coronary heart disease (CHD) and CHD complicating impaired glucose tolerance (IGT) .Methods 80 triers screened by the inclusion criteria were divided into the simple CHD group (36 cases) and the CHD complicating IGT group(44 cases);70 healthy cases were taken as the controls .Hcy ,FA and VB12 levels were measured and the detection results were performed the statistical analysis .Results The Hcy level in both experimental groups were higher than that in the control group , the difference was statistically significant (P<0 .05) ,the positive rates were 94 .4% in the simple CHD group and 88 .6% in the CHD complicating IGT group respectively ;The plasma FA level in both experimental groups were lower than that in the control group ,meanwhile ,plasma Hcy level and FA level showed a negative correlation (P<0 .05);The VB12 level had no statistical differ-ence among 3 groups (P>0 .05) ,and the correlation analysis between the Hcy level in the two experimental groups with VB 12 had no statistical significance (P>0 .05) .Conclusion Plasma Hcy level in CHD and CHD complicating IGT is very high and negatively correlated with the FA level ,dynamically detecting the Hcy level has an important significance for early warning and treatment of CHD and CHD complicating IGT .