CAJ | 학술논문

目的：探讨肺部疾病合并真菌感染患者血浆（1-3）-β-D葡聚糖（B G ）水平的动态变化与临床疗效的评价。方法应用M B-80微生物动态快速检测系统及真菌BG检测试剂盒检测87例肺部疾病合并真菌感染患者抗真菌治疗前、后与对照组血浆BG水平及对患者治疗前、后行痰液真菌培养。结果87例患者抗真菌药物治疗前、治疗1周后、2周后血浆BG水平分别为（162．81±70．03）、（15．89±30．88）、（4．58±7．87）pg/mL ，对照组血浆BG水平为（5．62±1．83）pg/mL ，治疗前患者血浆BG水平分别与治疗1周后、2周后水平及对照组比较差异有统计学意义（ P＜0．05）；治疗1周后患者血浆BG水平分别与治疗2周后和对照组比较差异有统计学意义（ P＜0．05）。87例患者抗真菌药物治疗1周后进痰液真菌培养阳性66例，治疗2周后培养阳性9例。结论通过连续监测患者血浆BG水平，结合痰液真菌培养结果及临床症状、肺部阴影情况判断临床抗真菌疗效有一定的临床价值。
목적：탐토폐부질병합병진균감염환자혈장（1-3）-β-D포취당（B G ）수평적동태변화여림상료효적평개。방법응용M B-80미생물동태쾌속검측계통급진균BG검측시제합검측87례폐부질병합병진균감염환자항진균치료전、후여대조조혈장BG수평급대환자치료전、후행담액진균배양。결과87례환자항진균약물치료전、치료1주후、2주후혈장BG수평분별위（162．81±70．03）、（15．89±30．88）、（4．58±7．87）pg/mL ，대조조혈장BG수평위（5．62±1．83）pg/mL ，치료전환자혈장BG수평분별여치료1주후、2주후수평급대조조비교차이유통계학의의（ P＜0．05）；치료1주후환자혈장BG수평분별여치료2주후화대조조비교차이유통계학의의（ P＜0．05）。87례환자항진균약물치료1주후진담액진균배양양성66례，치료2주후배양양성9례。결론통과련속감측환자혈장BG수평，결합담액진균배양결과급림상증상、폐부음영정황판단림상항진균료효유일정적림상개치。
Objective To investigate the dynamic change and the clinical curative effect evaluation of plasma (1-3)-beta glucan D (BG) in the patients with pulmonary disease complicating fungal infection .Methods The MB-80 miroorganism dynamic rapid de-tection system and fungi BG detection kits were adopted to detect plasma BG content before and after treatment in 87 cases of pul-monary disease complicating fungal infection and the controls .The sputum culture in the patients was performed before and after treatment .Results Plasma BG levels before antifungal therapy ,at 1 ,2 weeks after treatment in 87 patients were (162 .81 ± 70 .03) , (15 .89 ± 30 .88) and (4 .58 ± 7 .87)pg/mL ,which in the control group was (5 .62 ± 1 .83)pg/mL ,plasma BG level had statistical differences between before treatment and at 1 ,2 weeks after treatment in the patients with the control group (P<0 .05);Plasma BG levels between at 1 week after treatment with at 2 weeks after treatment and the control group had statistically significant differ-ences (P<0 .05) .Among 87 patients ,66 cases were positive sputum culture at 1 week after antifungal drug treatment and 9 cases were positive sputum culture at 2 weeks after treatment .Conclusion Continuously monitoring the patient′s plasma BG level com-bined with the sputum fungal culture results ,clinical symptoms and lung shadow in X-ray has certain clinical value to judge the anti-fungal effect .