当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
6期
34-36
,共3页
宫颈环形电切术%干扰素%宫颈上皮内瘤变%老年妇女
宮頸環形電切術%榦擾素%宮頸上皮內瘤變%老年婦女
궁경배형전절술%간우소%궁경상피내류변%노년부녀
Loop electrosurgical excision procedure%Interferon%Cervical intraepithelial neoplasia%Elderly women
目的：探讨宫颈环形电切术（LEEP）联合干扰素在治疗老年妇女宫颈上皮内瘤变（CIN）中的临床应用。方法对2010年1月-2013年1月经液基细胞学检查(TCT)、阴道镜定位活检、宫颈管搔刮术病理检查明确诊断为CINⅠ～Ⅲ的30例绝经后老年妇女，进行回顾性研究。对30例患者行LEEP前应用第二代杂交捕获试验（HC 2）检测高危型HPV DNA，并于治疗后联合应用干扰素3个疗程。治疗后分别于3、6、9、12个月，行TCT及阴道镜下可疑病变部位活检，6、12个月行HC2检测，以判断疗效。本研究中患者随诊时间为13～28个月。结果30例患者随诊中未发现CIN残留及复发。30例患者术后6个月复查，TCT 6例异常，HC2检测24例阴性，阴性率达80%；术后12个月治愈率达100%。结论宫颈环形电切术联合干扰素在治疗老年妇女宫颈上皮内瘤变中有双重阻断作用，提高患者一次性治愈率。
目的：探討宮頸環形電切術（LEEP）聯閤榦擾素在治療老年婦女宮頸上皮內瘤變（CIN）中的臨床應用。方法對2010年1月-2013年1月經液基細胞學檢查(TCT)、陰道鏡定位活檢、宮頸管搔颳術病理檢查明確診斷為CINⅠ～Ⅲ的30例絕經後老年婦女，進行迴顧性研究。對30例患者行LEEP前應用第二代雜交捕穫試驗（HC 2）檢測高危型HPV DNA，併于治療後聯閤應用榦擾素3箇療程。治療後分彆于3、6、9、12箇月，行TCT及陰道鏡下可疑病變部位活檢，6、12箇月行HC2檢測，以判斷療效。本研究中患者隨診時間為13～28箇月。結果30例患者隨診中未髮現CIN殘留及複髮。30例患者術後6箇月複查，TCT 6例異常，HC2檢測24例陰性，陰性率達80%；術後12箇月治愈率達100%。結論宮頸環形電切術聯閤榦擾素在治療老年婦女宮頸上皮內瘤變中有雙重阻斷作用，提高患者一次性治愈率。
목적：탐토궁경배형전절술（LEEP）연합간우소재치료노년부녀궁경상피내류변（CIN）중적림상응용。방법대2010년1월-2013년1월경액기세포학검사(TCT)、음도경정위활검、궁경관소괄술병리검사명학진단위CINⅠ～Ⅲ적30례절경후노년부녀，진행회고성연구。대30례환자행LEEP전응용제이대잡교포획시험（HC 2）검측고위형HPV DNA，병우치료후연합응용간우소3개료정。치료후분별우3、6、9、12개월，행TCT급음도경하가의병변부위활검，6、12개월행HC2검측，이판단료효。본연구중환자수진시간위13～28개월。결과30례환자수진중미발현CIN잔류급복발。30례환자술후6개월복사，TCT 6례이상，HC2검측24례음성，음성솔체80%；술후12개월치유솔체100%。결론궁경배형전절술연합간우소재치료노년부녀궁경상피내류변중유쌍중조단작용，제고환자일차성치유솔。
Objective To study The clinical application of combining loop electrosurgical excision procedure (LEEP) and interferon(INF) to treat cervical intraepithelial neoplasia(CIN) in elderly women. Methods From January 2010 to January 2013, retrospective study was progressed in thirty postmenopausal elderly women with CINI-CINIII diagnosed by liquid-based ThinPrep cytology test (TCT), colposcopic site-speciifc biopsies, curettage of cervical canals and pathological examination. Before carrying out LEEP to these patients, all women were performed high-risk HPV DNA detection by the method of hybrid capture 2 (HC2). All patients were added to use INF for three courses of treatment after LEEP. All patients were examined by TCT and colposcopic site-speciifc biopsies to doubtful focus of infection in the third, sixth, ninth and twelfth month after treating. And to judge the curative effect by using HC2 in the sixth and twelfth month after treating. The time of follow-up was from 13 to 28 months. Results Thirty patients were not detected residue and recidivation of CIN diagnosed by colposcopy and site-speciifc biopsies to doubtful focus of infection. In the group, 6 women were abnormal detected by TCT, 24 women were negative detected by HC2, the negative rate was 80%, when LEEP ended six months;the cure rate was 100%when LEEP ended twelve months. Conclusion It is double interrupted effect by combining LEEP and INF to treat CIN in elderly women. It can raise the one cure rate of the patients with CIN.
