CAJ | 학술논문

目的：研究复方一枝蒿片对小鼠的抗炎作用和免疫功能的影响，为其在临床中的合理用药提供病理学参考。方法：采用二甲苯致小鼠耳廓肿胀和毛细血管通透性实验观察复方一枝蒿片的抗炎作用；采用MTT比色法检测药物对刀豆蛋白A(ConA)诱导下T淋巴细胞的增殖作用影响，评价复方一枝蒿片对免疫功能的影响。结果：复方一枝蒿片2.5、5.0 g/kg剂量组对二甲苯致小鼠耳肿胀均有明显的抑制作用(P<0.01)；复方一枝蒿片1.5、2.5、5.0 g/kg剂量组对冰醋酸致小鼠腹腔毛细血管通透性的增高均有明显的抑制作用(P<0.01)；复方一枝蒿片在312~20000 mg/L能显著抑制ConA诱导的T淋巴细胞增殖作用(P<0.05)。结论：复方一枝蒿片具有良好的抗炎和调节免疫功能作用。
목적：연구복방일지호편대소서적항염작용화면역공능적영향，위기재림상중적합리용약제공병이학삼고。방법：채용이갑분치소서이곽종창화모세혈관통투성실험관찰복방일지호편적항염작용；채용MTT비색법검측약물대도두단백A(ConA)유도하T림파세포적증식작용영향，평개복방일지호편대면역공능적영향。결과：복방일지호편2.5、5.0 g/kg제량조대이갑분치소서이종창균유명현적억제작용(P<0.01)；복방일지호편1.5、2.5、5.0 g/kg제량조대빙작산치소서복강모세혈관통투성적증고균유명현적억제작용(P<0.01)；복방일지호편재312~20000 mg/L능현저억제ConA유도적T림파세포증식작용(P<0.05)。결론：복방일지호편구유량호적항염화조절면역공능작용。
Objective:To investigate immunization and the anti-inflammatory effect of compound Artemisia Rupestris tablet to provide the reference for the clinical treatment of influenza.Method:Using the xylene-induced mouse ear edema and capillary permeability test to investigate anti-inflammatory effects.Drug on effects of ConA induced T lymphocyte proliferation was measured by MTT colorimetric assay.Result:Compound Artemisia Rupestris tablet 2.5,5.0 g/kg dose could significantly inhibited xylenen-induced ear edema in mice (P<0.01);Compound Artemisia Rupestris tablet (1.5,2.5,5.0 g/kg dose) could significantly inhibited acetic acid-induced increase in capillary permeability in mice;Compound Artemisia Rupestris tablet 312-20 000 mg/L concentration range can suppress ConA-induced T cell proliferation(P<0.05).Conclusion:Compound Artemisia Rupestris tablet have anti-inflammatory and immunoregulation function.