中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
8期
22-23,24
,共3页
地诺前列酮栓%足月妊娠%宫颈成熟%引产
地諾前列酮栓%足月妊娠%宮頸成熟%引產
지낙전렬동전%족월임신%궁경성숙%인산
Dinoprostone%Term pregnancy%Cervical ripening%Induced labor
目的：研究地诺前列酮栓（欣普贝生）用于足月引产的有效性及安全性。方法：选取140例有引产指征的单胎初产妇，按照随机数字表法分为研究组（欣普贝生治疗组）64例和对照组（缩宫素治疗组）76例。比较两组孕妇用药后促宫颈成熟有效率、引产效果、分娩情况、新生儿情况及不良反应。结果：研究组促宫颈成熟的总有效率为93.75%，对照组为75.00%，两组比较差异有统计学意义（P<0.01）。从开始用药至临产的时间研究组显著短于对照组，两组比较差异有统计学意义（P<0.05）。研究组的阴道分娩率为70.31%，对照组为47.37%，两组比较差异有统计学意义（P<0.05）。两组产后出血量和新生儿窒息率比较差异均无统计学意义（P>0.05）。欣普贝生的主要副作用是子宫过度刺激，发生率为3.12%。结论：地诺前列酮栓（欣普贝生）促宫颈成熟效果优于缩宫素，可安全、有效地用于足月引产。
目的：研究地諾前列酮栓（訢普貝生）用于足月引產的有效性及安全性。方法：選取140例有引產指徵的單胎初產婦，按照隨機數字錶法分為研究組（訢普貝生治療組）64例和對照組（縮宮素治療組）76例。比較兩組孕婦用藥後促宮頸成熟有效率、引產效果、分娩情況、新生兒情況及不良反應。結果：研究組促宮頸成熟的總有效率為93.75%，對照組為75.00%，兩組比較差異有統計學意義（P<0.01）。從開始用藥至臨產的時間研究組顯著短于對照組，兩組比較差異有統計學意義（P<0.05）。研究組的陰道分娩率為70.31%，對照組為47.37%，兩組比較差異有統計學意義（P<0.05）。兩組產後齣血量和新生兒窒息率比較差異均無統計學意義（P>0.05）。訢普貝生的主要副作用是子宮過度刺激，髮生率為3.12%。結論：地諾前列酮栓（訢普貝生）促宮頸成熟效果優于縮宮素，可安全、有效地用于足月引產。
목적：연구지낙전렬동전（흔보패생）용우족월인산적유효성급안전성。방법：선취140례유인산지정적단태초산부，안조수궤수자표법분위연구조（흔보패생치료조）64례화대조조（축궁소치료조）76례。비교량조잉부용약후촉궁경성숙유효솔、인산효과、분면정황、신생인정황급불량반응。결과：연구조촉궁경성숙적총유효솔위93.75%，대조조위75.00%，량조비교차이유통계학의의（P<0.01）。종개시용약지임산적시간연구조현저단우대조조，량조비교차이유통계학의의（P<0.05）。연구조적음도분면솔위70.31%，대조조위47.37%，량조비교차이유통계학의의（P<0.05）。량조산후출혈량화신생인질식솔비교차이균무통계학의의（P>0.05）。흔보패생적주요부작용시자궁과도자격，발생솔위3.12%。결론：지낙전렬동전（흔보패생）촉궁경성숙효과우우축궁소，가안전、유효지용우족월인산。
Objective:To explore the effect and safety of dinoprostone on induction of term pregnancy. Method:One hundred and forty single births primipara with indications for induction of labor were randomly divided into two groups:the study group(64 cases,treated with dinoprostone)and the control group(76 cases,treated with oxytocin). The overall rate of cervical ripening,medication effects,vaginal delivery,neonatal outcome and adverse reaction between the two groups were compared. Result:The total effective rate of promoting cervical ripening in study group was 93.75%,significantly higher than 75.00%of control group(P<0.01).The time from medication to parturition in study group was significantly shorter than the control group(P<0.05). Vaginal delivery rate in study group was 70.31%,while which in control group was only 47.37%, the difference was statistically significant(P<0.05).There were no significant differences in postpartum hemorrhage and neonatal asphyxia rate between two groups. The major side effect of dinoprostone was uterine hyperstimulation and the incidence in study group was 3.12%. Conclusion:Dinoprostone is more effective than oxytocin in cervical ripening,and can be used for induction of term pregnancy effectively and safely.
