岭南急诊医学杂志
嶺南急診醫學雜誌
령남급진의학잡지
LINGNAN JOURNAL OF EMERGENCY MEDICINE
2014年
2期
122-124
,共3页
Th17 细胞%白细胞介素-10%婴幼儿喘息%哮喘预测指数
Th17 細胞%白細胞介素-10%嬰幼兒喘息%哮喘預測指數
Th17 세포%백세포개소-10%영유인천식%효천예측지수
Th-17 cell%interleukin-10%infant wheezing%asthma predicting index
目的：探讨外周血辅助性 T 淋巴细胞17（Th-17），白细胞介素-10（IL-10）与哮喘预测指数（API）阳性患儿喘息的相关性。方法：将62例喘息性儿童分为 API 阳性组（n＝30）、API 阴性组（n＝32）和正常对照组（n＝35），使用流式细胞术及ELISA法测定Th-17百分数及血清IL-10浓度。结果：API阳性组及API阴性组Th-17百分数均低于正常对照组，且API阳性组的Th-17百分数也低于API阴性组，但差异均无统计学意义（P＞0．05）；API阳性组血清 IL-10浓度明显高于正常儿童组（P＜0．05），API 阳性组血清 IL-10浓度高于 API 阴性组， API阴性组血清 IL-10也高于正常儿童组，但差异均无统计学意义（P＞0．05）。结论：IL-10与 API 阳性患儿喘息有相关性，Th-17百分数与API阳性患儿喘息不相关。
目的：探討外週血輔助性 T 淋巴細胞17（Th-17），白細胞介素-10（IL-10）與哮喘預測指數（API）暘性患兒喘息的相關性。方法：將62例喘息性兒童分為 API 暘性組（n＝30）、API 陰性組（n＝32）和正常對照組（n＝35），使用流式細胞術及ELISA法測定Th-17百分數及血清IL-10濃度。結果：API暘性組及API陰性組Th-17百分數均低于正常對照組，且API暘性組的Th-17百分數也低于API陰性組，但差異均無統計學意義（P＞0．05）；API暘性組血清 IL-10濃度明顯高于正常兒童組（P＜0．05），API 暘性組血清 IL-10濃度高于 API 陰性組， API陰性組血清 IL-10也高于正常兒童組，但差異均無統計學意義（P＞0．05）。結論：IL-10與 API 暘性患兒喘息有相關性，Th-17百分數與API暘性患兒喘息不相關。
목적：탐토외주혈보조성 T 림파세포17（Th-17），백세포개소-10（IL-10）여효천예측지수（API）양성환인천식적상관성。방법：장62례천식성인동분위 API 양성조（n＝30）、API 음성조（n＝32）화정상대조조（n＝35），사용류식세포술급ELISA법측정Th-17백분수급혈청IL-10농도。결과：API양성조급API음성조Th-17백분수균저우정상대조조，차API양성조적Th-17백분수야저우API음성조，단차이균무통계학의의（P＞0．05）；API양성조혈청 IL-10농도명현고우정상인동조（P＜0．05），API 양성조혈청 IL-10농도고우 API 음성조， API음성조혈청 IL-10야고우정상인동조，단차이균무통계학의의（P＞0．05）。결론：IL-10여 API 양성환인천식유상관성，Th-17백분수여API양성환인천식불상관。
Objective: To investigate the correlation of Th-17 cell (Th-17),interleukin-10 (IL-10) in the peripheral blood with asthma predicting index (API)positive infantile wheezing. Methods: 97 patients with infantile wheezing were divided into API positive group(n=30), API negative group(n=32) and normal control group(n=35). We performed flow cytometric analyze the accumulation of percentage of Th-17 cell and performed ELISA analyze the accumulation of Serum concentration of IL-10. Results: Th-17 percentage in both the API positive group and the API negative group were lower than that normal control group , and Th-17 percentage in API positive group was lower than that in API negative group, there was no significantly difference among the three groups(P > 0.05). The serum IL-10 concentration in API positive group was higher than that in the API negative group , There was no significantly difference between the two groups (P > 0.05). The serum IL-10 concentration in API positive group was significantly higher than that in the normal control group(P < 0.05). The serum IL-10 concentration in the API negative group was higher than that in the API negative group, but there was no significantly difference between the two groups (P >0.05). Conclusion:The serum IL-10 concentration is related to API positive infantile wheezing. Th-17 percentage is not associated with API positive infantile wheezing.
