医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
8期
76-77
,共2页
氨曲南%粉针剂%制备工艺%质量控制
氨麯南%粉針劑%製備工藝%質量控製
안곡남%분침제%제비공예%질량공제
Aztreonam%Powder injection%Preparation technology%Quality control
氨曲南是一种对大多数需氧型革兰阴性菌具有高度的抗菌活性的药物，现已广泛应用于下呼吸道感染等疾病的临床治疗。本研究通过改进氨曲南制备方法制备出一种高质量的氨曲南组合物，所述方法原料易得，步骤简单，可操作性强。通过对其无菌粉针剂的引湿性和稳定性等相关因素进行考察，表明该粉针剂稳定性和澄清度等指标均表现较好，水分含量低，可以作为注射用氨曲南粉针剂使用。
氨麯南是一種對大多數需氧型革蘭陰性菌具有高度的抗菌活性的藥物，現已廣汎應用于下呼吸道感染等疾病的臨床治療。本研究通過改進氨麯南製備方法製備齣一種高質量的氨麯南組閤物，所述方法原料易得，步驟簡單，可操作性彊。通過對其無菌粉針劑的引濕性和穩定性等相關因素進行攷察，錶明該粉針劑穩定性和澄清度等指標均錶現較好，水分含量低，可以作為註射用氨麯南粉針劑使用。
안곡남시일충대대다수수양형혁란음성균구유고도적항균활성적약물，현이엄범응용우하호흡도감염등질병적림상치료。본연구통과개진안곡남제비방법제비출일충고질량적안곡남조합물，소술방법원료역득，보취간단，가조작성강。통과대기무균분침제적인습성화은정성등상관인소진행고찰，표명해분침제은정성화징청도등지표균표현교호，수분함량저，가이작위주사용안곡남분침제사용。
Aztreonam is a kind of drugs with high antibacterial activity for the majority of aerobic gram-negative bacteria and has been widely used in lower respiratory tract infections and other diseases in clinical treatment. In this study,a high quality aztreonam composition has been prepared by improving the preparation method of aztreonam. This method has readily available raw materials,simple steps,and operable processes. Through inspecting hygroscopic,stability and the relevant factors of Aztreonam asepsis powder,the stability and clarity and other indicators of Aztreonam powder have bet er performance.And the powder has low moisture content,can be used as aztreonam powder for injection.
