CAJ | 학술논문

目的：观察熊去氧胆酸胶囊（优思弗）联合丁二磺酸腺苷蛋氨酸（思美泰）治疗肝硬化黄疸的疗效。方法肝硬化黄疸患者共46例，治疗组（23例）用熊去氧胆酸胶囊[UDCA 13～15mg/（kg·d），口服，Bid或Tid]联合丁二磺酸腺苷蛋氨酸（思美泰1000mg/d，静脉滴注）治疗，不使用甘草酸制剂等保肝药；对照组应用丁二磺酸腺苷蛋氨酸，其余药物基本相同。疗程2周，观察临床症状、肝功能的变化。结果经治疗后两组患者临床症状均有明显改善，肝功能指标均有好转，治疗组TBil下降更明显（P＜0.05）。结论熊去氧胆酸联合丁二磺酸腺苷蛋氨酸治疗肝硬化黄疸效果更好。
목적：관찰웅거양담산효낭（우사불）연합정이광산선감단안산（사미태）치료간경화황달적료효。방법간경화황달환자공46례，치료조（23례）용웅거양담산효낭[UDCA 13～15mg/（kg·d），구복，Bid혹Tid]연합정이광산선감단안산（사미태1000mg/d，정맥적주）치료，불사용감초산제제등보간약；대조조응용정이광산선감단안산，기여약물기본상동。료정2주，관찰림상증상、간공능적변화。결과경치료후량조환자림상증상균유명현개선，간공능지표균유호전，치료조TBil하강경명현（P＜0.05）。결론웅거양담산연합정이광산선감단안산치료간경화황달효과경호。
Objective To observe the therapeutic effect of combined therapy of ursodeoxycholic acid capsules(ursofalk) and ademetionine(transmetil) in patients with jaundice from cirrhosis. Methods Forty six patients of jaundice from cirrhosis were randomly divided into treatment group(n=23) and control group(n=23). Liver protection and supportive treatments were not given for the two groups. Ursodeoxycholic acid capsules[10-15mg/(kg·d), two or three times a day,for oral use] and ademetionine(Transmetil 1000mg/d intravenous drip) were given for the treatment group;the same treatments were given to the control group except ursodeoxycholic acid capsules.The treatment duration was 2 weeks in both groups.The liver function(TBIL,TBA,ALT and AST), clinical symptom and physical sign were compared before and after being treated. Results After being treated,the liver function,clinical symptom and physical sign of treatment group got better.There was significant difference between two groups(P < 0.05). Conclusion The combined treatment of ursodeoxycholic acid and ademetionine could obtain better curative effect.