CAJ | 학술논문

该文研究了以混合脂肪酸为原料，通过薄膜精馏制备药品级亚油酸的工艺。考察了不同的精馏温度和回流比对饱和脂肪酸分离效果的影响，确定了三级分离工艺。在蒸发温度90℃、压力1000 Pa条件下，进行一级薄膜蒸发，脱除物料中的溶剂、水等轻物质；在精馏温度238℃、压力300 Pa和回流比为10条件下，进行二级薄膜精馏，分离出轻组分饱和脂肪酸，获得碘价148 gI/100g的重组分样品；在蒸发温度265℃、压力300 Pa条件下，进行三级薄膜蒸发，收集轻组分不饱和脂肪酸。轻组分样品碘价达到151.8 gI/100g，亚油酸含量为58.00%，符合了药品级亚油酸的要求。
해문연구료이혼합지방산위원료，통과박막정류제비약품급아유산적공예。고찰료불동적정류온도화회류비대포화지방산분리효과적영향，학정료삼급분리공예。재증발온도90℃、압력1000 Pa조건하，진행일급박막증발，탈제물료중적용제、수등경물질；재정류온도238℃、압력300 Pa화회류비위10조건하，진행이급박막정류，분리출경조분포화지방산，획득전개148 gI/100g적중조분양품；재증발온도265℃、압력300 Pa조건하，진행삼급박막증발，수집경조분불포화지방산。경조분양품전개체도151.8 gI/100g，아유산함량위58.00%，부합료약품급아유산적요구。
This article investigated purifying process of pharmaceutical grade soybean lionleic acid by film evaporation with distillation column from mixed fatty acids. The related factors influencing the separation of saturated fatty acid such as temperature and reflux ratio were studied through single-factor experiments. The three-stage separation process was determined. The solvent and water in the raw material were be removed in the one-stage film evaporation under the condition of temperature 90℃and pressure 1 000 Pa. The saturated fatty acids were separated in the two-stage rectification under the condition of distillation temperature 238℃,pressure 300 Pa and reflux ratio of 10. Iodine value of the heavy component was 148 gI/100g. Unsaturated fatty acids were collected as light component in the three-stage film evaporation under the condition of temperature 265℃ and pressure 300 Pa. Iodine value of light component reached 151.8 gI/100g and the content of linoleic acid was 58.00%,according with the requirement of pharmaceutical grade soybean lionleic acid.