CAJ | 학술논문

目的：探讨来士普联合认知疗法治疗老年抑郁症的临床疗效和安全性。方法我院诊治的84例老年抑郁症患者，随机将其分为对照组（来士普治疗）和观察组（来士普联合认知疗法治疗），每组各42例，根据汉密顿抑郁量表（HAMD）及生活指数评分指数（QLI），对两组治疗前后抑郁程度及生活质量进行观察和比较，并监测治疗期间不良反应。结果与对照组相比，治疗后观察组HAMD评分明显降低（25.0±4.0 vs 33.5±4.5），QLI评分明显升高（8.7±1.5 vs 6.2±1.2），P＜0.05；治疗期间，两组都没有出现明显不良反应。结论对于老年抑郁症患者，来士普联合认知疗法治疗明显改善患者的抑郁程度和生活质量，值得临床推广。
목적：탐토래사보연합인지요법치료노년억욱증적림상료효화안전성。방법아원진치적84례노년억욱증환자，수궤장기분위대조조（래사보치료）화관찰조（래사보연합인지요법치료），매조각42례，근거한밀돈억욱량표（HAMD）급생활지수평분지수（QLI），대량조치료전후억욱정도급생활질량진행관찰화비교，병감측치료기간불량반응。결과여대조조상비，치료후관찰조HAMD평분명현강저（25.0±4.0 vs 33.5±4.5），QLI평분명현승고（8.7±1.5 vs 6.2±1.2），P＜0.05；치료기간，량조도몰유출현명현불량반응。결론대우노년억욱증환자，래사보연합인지요법치료명현개선환자적억욱정도화생활질량，치득림상추엄。
Objective To study the clinical efficacy and safety of lexapro combined with cognitive therapy for patients with senile depression. Methods 84 patients with senile depression were randomized into the control group(lexapro treatment) and the observation group(lexapro combined with cognitive therapy), 42 patients per group. The depression level and life quality in the two groups between pre-treatment and post-treatment were observed and compared according to the hamilton depression scale(HAMD) and quality of life index(QLI). The adverse reaction in the two groups during the treatment period was monitored. Results Compared with the control group, the HAMD scores were obviously decreased(25.0±4.0 vs 33.5±4.5) and QLI scores were significantly increased(8.7±1.5 vs 6.2±1.2) in the observation group on the post-treatment, P<0.05; there were no obvious adverse reactions during the treatment period. Conclusion For the patients with senile depression, the treatment of lexapro combined with cognitive therapy can significantly improve the depression level and life quality and is worthy of clinical promotion.