CAJ | 학술논문

目的：观察多奈哌齐与天智颗粒联合治疗轻、中度阿尔茨海默病（Alzheimer’s disease ，AD）的临床疗效。方法选择简易智能量表（MMSE）评分在10～24分的轻、中度AD患者84例，随机分成2组。联合治疗组43例给予多奈哌齐5
목적：관찰다내고제여천지과립연합치료경、중도아이자해묵병（Alzheimer’s disease ，AD）적림상료효。방법선택간역지능량표（MMSE）평분재10～24분적경、중도AD환자84례，수궤분성2조。연합치료조43례급여다내고제5
Objective To investigate the curative effect of donepezil combined with Tianzhi granule on mild to moderate Alzheimer’s disease(AD).Methods Eighty-four patients with mild to moderate AD (Mini Mental State Examination(MMSE) total scores between 10 and 24) were randomly divided into two groups :combined treatment group (n= 43) ,treated with donepezil 5 mg once a day and Tianzhi granule 5 g three times a day ;control group (n=41) treated with donepezil 5 mg ,once a day.The treatment lasted for 12 weeks. MMSE and Activity of Daily Living Scale (ADL) were used to evaluate clinical effica-cy.Results MMSE and ADL scores were improved significantly after treatments in two groups (P< 0.01). The scores of combined treatment goup were improved more significantly than that of control group (P< 0.05). There were 4 patients (9.3% )with mild diarrhea in treatment group ;1 patient (2.4% )with mild diarrhea and 5 patients(12.2% )with excitation and insomnia in control group.Conclusion Donepezil combined with Tianzhi granule is effective on patients with mild and moderate AD. It could produce improvements in cognition and ability of daily life.Clinical effects of Donepezil combined with Tianzhi granule are batter than that of Donepezil.