CAJ | 학술논문

目的：应用 GK 大鼠建立旷置不同长度小肠的 Roux-en-Y 胃旁路术（RYGBP）动物模型。方法50只GK大鼠随机分为5组，每组10只，分别实施旷置不同长度小肠的胃旁路术式。A组：假手术组，无肠段旷置；B组：旷置十二指肠；C组：旷置十二指肠＋近端1/5空肠；D组：旷置十二指肠＋近端1/3空肠；E组：旷置十二指肠＋近端1/2空肠。观察各组大鼠存活情况；比较各组大鼠术前、术后空腹血糖变化情况。结果共死亡3只大鼠，余各组大鼠长期健康存活，全组大鼠手术存活率94%。除假手术组外，余各组空腹血糖均有不同程度改善。结论 RYGBP对GK大鼠具有确切的改善糖代谢的作用，通过GK大鼠建立旷置不同长度小肠的RYGBP动物模型是可行的，可用于长期观察及相关检测研究，有助于胃旁路术机制研究、小肠旷置长度与降糖效果研究及手术远期效果的观察。
목적：응용 GK 대서건립광치불동장도소장적 Roux-en-Y 위방로술（RYGBP）동물모형。방법50지GK대서수궤분위5조，매조10지，분별실시광치불동장도소장적위방로술식。A조：가수술조，무장단광치；B조：광치십이지장；C조：광치십이지장＋근단1/5공장；D조：광치십이지장＋근단1/3공장；E조：광치십이지장＋근단1/2공장。관찰각조대서존활정황；비교각조대서술전、술후공복혈당변화정황。결과공사망3지대서，여각조대서장기건강존활，전조대서수술존활솔94%。제가수술조외，여각조공복혈당균유불동정도개선。결론 RYGBP대GK대서구유학절적개선당대사적작용，통과GK대서건립광치불동장도소장적RYGBP동물모형시가행적，가용우장기관찰급상관검측연구，유조우위방로술궤제연구、소장광치장도여강당효과연구급수술원기효과적관찰。
Objective To establish of Goto-Kakizaki diabetes prone rat model with Roux-en-Y gastric bypass (RYGBP) surgery by different length of small intestine exclusion. Methods 50 GK rats were randomly divided into 5 groups, Group A:sham-operation, no small intestine exclusion, Group B:The duodenal exclusion, Group C: The duodenal and the proximal 1/5 jejunum exclusion, Group D: The duodenal and the proximal 1/3 jejunum exclusion, Group E:The duodenal and the proximal 1/2 jejunum exclusion. Fasting glucose changes were compared with that on 1, 4, 8, 12 weeks after operation. Results Three rats died, the rest group rats live healthy, surgical survival rate 94%. Every group fasting glucose was improved to varying degrees except the control group. Conclusions Roux-en-Y gastric bypass surgery exactly improve glucose metabolism in GK rats. The establishment of Goto-Kakizaki diabetes prone rat model with RYGBP surgery by different length of small intestine exclusion is feasible, and can be used for long-term observation and detection research. This model can contribute to the research of gastric bypass mechanism and effects of gastric bypass with different length of small intestine exclusion, to observe the long-term effect of the operation.