CAJ | 학술논문

目的：观察5-羟色胺3受体拮抗剂昂丹司琼对腰硬联合麻醉下剖宫产术中及术后不同原因恶心呕吐的防治效果。方法择期及急诊剖宫产手术患者280例，随机分为对照组和昂丹司琼组，每组140例；昂丹司琼组在夹闭脐静脉即刻静脉注射昂丹司琼8 mg，对照组注射生理盐水4 ml，观察术中、术后恶心呕吐的发生率。结果与对照组相比，昂丹司琼组不但术中恶心呕吐总发生率显著下降（P＜0.05），饱胃患者恶心呕吐发生率降低（P＜0.05）；而且术后恶心呕吐总发生率也显著下降（P＜0.05），使用PCEA患者中、重度恶心呕吐发生率明显减少（P＜0.05）。结论昂丹司琼可有效防治饱胃患者的术中恶心呕吐，同时可有效减少PCEA患者术后恶心呕吐的发生。
목적：관찰5-간색알3수체길항제앙단사경대요경연합마취하부궁산술중급술후불동원인악심구토적방치효과。방법택기급급진부궁산수술환자280례，수궤분위대조조화앙단사경조，매조140례；앙단사경조재협폐제정맥즉각정맥주사앙단사경8 mg，대조조주사생리염수4 ml，관찰술중、술후악심구토적발생솔。결과여대조조상비，앙단사경조불단술중악심구토총발생솔현저하강（P＜0.05），포위환자악심구토발생솔강저（P＜0.05）；이차술후악심구토총발생솔야현저하강（P＜0.05），사용PCEA환자중、중도악심구토발생솔명현감소（P＜0.05）。결론앙단사경가유효방치포위환자적술중악심구토，동시가유효감소PCEA환자술후악심구토적발생。
Objective To observe the efficacy of intravenous 5-hydroxytryptamine 3 receptor antagonist in the prevention of nausea and vomiting while and after cesarean section (CS). Methods A total of 280 pregnant women with American Society of Anesthesiologists (ASA) Physical Status Ⅰ-Ⅱ who underwent emergency and elective CS under combined spinal-epidural anesthesia (CSEA) were randomly divided into two groups (n=140):in clamping the umbilical vein immediately intravenous ondansetron 8 mg (ondansetron group) or 0.9% normal saline 4 ml (control group) were intravenously infused, respectively. The episodes of nausea and vomiting intraoperatively and postoperatively were observed. Results In ondansetron group, the incidence of intra- and post-operative nausea and vomiting reduced significantly compared with the control group, and the incidences of intraoperative severe nausea and vomiting in full stomach patients of ondansetron group were 6.5%, which were significantly lower than that in control group. The incidences of postoperative moderate and severe nausea and vomiting patients who using PCEA of ondansetron were significantly lower than that in control group (P<0.05). Conclusion Ondansetron has better treatment for intra- and post-operative nausea and vomiting caused by full stomach and PCEA.