CAJ | 학술논문

目的：探讨术前服用非那雄胺减少经尿道前列腺电切术（TURP）中出血的疗效及机制。方法随机对96例住院行TURP的患者进行分组，其中A组23例服用非那雄胺3个月；B组32例服用非那雄胺1个月；C组20例服用非那雄胺及坦索罗辛3个月；D组21例未服用任何前列腺增生症方面的药。术中计算失血量，术后检测前列腺组织中微血管密度（MVD），并比较各组之间的差异。结果 A组与B组术中出血量差异无统计学意义（P＞0.05），但前列腺 MVD 差异有统计学意义（P＜0.05）；A组与C组术中出血量及MVD均无统计学差异（P＞0.05）；与D组比较，A、B、C组术中出血量和前列腺MVD明显下降，差异有统计学意义（P＜0.01）。结论良性前列腺增生患者术前服用非那雄胺1个月以上再行电切术，可明显减少术中出血。
목적：탐토술전복용비나웅알감소경뇨도전렬선전절술（TURP）중출혈적료효급궤제。방법수궤대96례주원행TURP적환자진행분조，기중A조23례복용비나웅알3개월；B조32례복용비나웅알1개월；C조20례복용비나웅알급탄색라신3개월；D조21례미복용임하전렬선증생증방면적약。술중계산실혈량，술후검측전렬선조직중미혈관밀도（MVD），병비교각조지간적차이。결과 A조여B조술중출혈량차이무통계학의의（P＞0.05），단전렬선 MVD 차이유통계학의의（P＜0.05）；A조여C조술중출혈량급MVD균무통계학차이（P＞0.05）；여D조비교，A、B、C조술중출혈량화전렬선MVD명현하강，차이유통계학의의（P＜0.01）。결론량성전렬선증생환자술전복용비나웅알1개월이상재행전절술，가명현감소술중출혈。
Objective To discuss the clinical effect mechanism of preoperative finasteride and tamsulosin on decreasing operative bleeding during TURP with patient of benign prostatic hyperplasia. Methods During a randomized controlled trial, 96 cases of hospitalized patients which were scheduled for TURP were divided into four groups: 23 of them were received finasteride for over three months(A group), 32 of them were received finasteride for one month(B group), 20 of them were received finasteride and tamsulosin for three months (C group)and the other 21 patients have not taken any medicine for BPH(D group). To calculate bleeding volume during operation; After surgery, testing microvascular density(MVD) in prostate tissue and comparing the difference among all the groups. Results The bleeding amount has no statistically significant difference between group A and B (P>0.05), but the prostate MVD was statistically significant difference(P<0.05);Compared with group C, interoperative blood loss and MVD decreases obviously in group A and B, the difference was statistically significant(P<0.01). Conlusion Finasteride administration for more than one month before operation can effectively decrease the blood loss during TURP.