中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
24期
11309-11312
,共4页
肿瘤,鳞状细胞%STAT3转录因子%药物疗法,联合%细胞周期素D1
腫瘤,鱗狀細胞%STAT3轉錄因子%藥物療法,聯閤%細胞週期素D1
종류,린상세포%STAT3전록인자%약물요법,연합%세포주기소D1
Neoplasms,squamous cell%STAT3 Transcription factor%Drug therapy,Combination%CyclinD1
目的：探讨STAT3和CyclinD1在口腔高分化鳞状细胞癌化疗前后的表达及其与预后的关系。方法选择2003年1月至2013年6月在我院接受手术治疗的高分化口腔鳞状细胞癌72例，其中术前未化疗组34例，术前静脉化疗组38例，免疫组化法检测STAT3和CyclinD1的表达，并分析STAT3和CyclinD1的表达与肿瘤大小、性别、年龄、淋巴结转移及临床分期之间的关系。结果与未化疗组相比，术前化疗可以明显降低高分化口腔鳞癌中STAT3和CyclinD1的阳性率；STAT3和CyclinD1表达情况与高分化口腔鳞状细胞癌的淋巴结转移、部位及临床分期（T1、T2）相关（P＜0.05），而与患者的年龄、性别、瘤体大小及T3期无关（P＞0.05）。结论术前化疗可以降低高分化口腔鳞癌中STAT3和CyclinD1的表达，进而减少淋巴结的转移和改善预后。
目的：探討STAT3和CyclinD1在口腔高分化鱗狀細胞癌化療前後的錶達及其與預後的關繫。方法選擇2003年1月至2013年6月在我院接受手術治療的高分化口腔鱗狀細胞癌72例，其中術前未化療組34例，術前靜脈化療組38例，免疫組化法檢測STAT3和CyclinD1的錶達，併分析STAT3和CyclinD1的錶達與腫瘤大小、性彆、年齡、淋巴結轉移及臨床分期之間的關繫。結果與未化療組相比，術前化療可以明顯降低高分化口腔鱗癌中STAT3和CyclinD1的暘性率；STAT3和CyclinD1錶達情況與高分化口腔鱗狀細胞癌的淋巴結轉移、部位及臨床分期（T1、T2）相關（P＜0.05），而與患者的年齡、性彆、瘤體大小及T3期無關（P＞0.05）。結論術前化療可以降低高分化口腔鱗癌中STAT3和CyclinD1的錶達，進而減少淋巴結的轉移和改善預後。
목적：탐토STAT3화CyclinD1재구강고분화린상세포암화료전후적표체급기여예후적관계。방법선택2003년1월지2013년6월재아원접수수술치료적고분화구강린상세포암72례，기중술전미화료조34례，술전정맥화료조38례，면역조화법검측STAT3화CyclinD1적표체，병분석STAT3화CyclinD1적표체여종류대소、성별、년령、림파결전이급림상분기지간적관계。결과여미화료조상비，술전화료가이명현강저고분화구강린암중STAT3화CyclinD1적양성솔；STAT3화CyclinD1표체정황여고분화구강린상세포암적림파결전이、부위급림상분기（T1、T2）상관（P＜0.05），이여환자적년령、성별、류체대소급T3기무관（P＞0.05）。결론술전화료가이강저고분화구강린암중STAT3화CyclinD1적표체，진이감소림파결적전이화개선예후。
Objective To detect the effect of chemotherapy administered before surgery on the expression of STAT3 and CyclinD1 in the well-differentiated oral cavity squamous cell carcinoma.We also correlated expression of STAT3 and CyclinD1 with clinical outcome. Methods 60 cases specimens of well-differentiated oral squamous cell carcinoma were collected from patients between January 2003 to June 2013. They were divided into two groups, nonchemotherapy before operation group (n=34) and intravenous chemotherapy before operation group (n = 38). The expressions of STAT3 and CyclinD1 were determined by immunohistochemical.The expressions of STAT3 and CyclinD1 correlated with size of tumor, gender, age, lymph node metastasis and clinical stages was also determined. Results Chemotherapy administered before surgery significantly reduced the expression of STAT3 and CyclinD1(P<0.05). There were significant differences in the lymph node metastasis, location, clinical stages(T1,2) between the two groups(P<0.05). However, there was no significant difference in the tumor size, T3, gender and age between the two groups(P>0.05). Conclusion Chemotherapy given before surgery reduced the STAT3 and CyclinD1 expression rate, restrained lymph node metastasis and improved clinical outcomes.
