中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
24期
11136-11139
,共4页
黄茵%黄涌泉%薛金方%陈晓波%郭辉%韩君勇%林岫芳
黃茵%黃湧泉%薛金方%陳曉波%郭輝%韓君勇%林岫芳
황인%황용천%설금방%진효파%곽휘%한군용%림수방
高血压%心室重构%超声心动描记术%胱抑素C
高血壓%心室重構%超聲心動描記術%胱抑素C
고혈압%심실중구%초성심동묘기술%광억소C
Hypertension%Ventricular remodeling%Echocardiography%CystatinC
目的：研究原发性高血压（EH）患者血清胱抑素C（Cys C）与心脏重构的相关性。方法纳入收缩功能正常（LVEF＞50%）的EH患者200例为试验组，纳入正常体检者50例为对照组，对上述对象进行血清CysC浓度检测并行超声心动图检查，测量左心房内径（LAD）、左心室舒张末期内径（LVDD）、室间隔厚度（IVS）、左心室后壁厚度（LVPW），并计算左心室重量指数（LVMI）；对照组上述指标正常，试验组根据血清CysC中位数浓度（1.05 mg/L）分为CysC升高组（98例）及CysC正常组（102例）。结果试验组较对照组血清CysC浓度明显升高（P＜0.05）。CysC升高组的LAD、LVDD、IVS、LVPW、LVMI较CysC正常组显著增高（P＜0.05）。CysC含量与LAD、LVDD、IVS、LVPW、LVMI呈正相关关系（相关系数分别为0.422、0.381、0.367、0.256、0.350，P＜0.05），血清CysC浓度是心脏重构的显著影响因素。结论原发性高血压患者血清CysC浓度与心脏重构相关，对高血压心脏重构的程度及预后判断有一定预测价值。
目的：研究原髮性高血壓（EH）患者血清胱抑素C（Cys C）與心髒重構的相關性。方法納入收縮功能正常（LVEF＞50%）的EH患者200例為試驗組，納入正常體檢者50例為對照組，對上述對象進行血清CysC濃度檢測併行超聲心動圖檢查，測量左心房內徑（LAD）、左心室舒張末期內徑（LVDD）、室間隔厚度（IVS）、左心室後壁厚度（LVPW），併計算左心室重量指數（LVMI）；對照組上述指標正常，試驗組根據血清CysC中位數濃度（1.05 mg/L）分為CysC升高組（98例）及CysC正常組（102例）。結果試驗組較對照組血清CysC濃度明顯升高（P＜0.05）。CysC升高組的LAD、LVDD、IVS、LVPW、LVMI較CysC正常組顯著增高（P＜0.05）。CysC含量與LAD、LVDD、IVS、LVPW、LVMI呈正相關關繫（相關繫數分彆為0.422、0.381、0.367、0.256、0.350，P＜0.05），血清CysC濃度是心髒重構的顯著影響因素。結論原髮性高血壓患者血清CysC濃度與心髒重構相關，對高血壓心髒重構的程度及預後判斷有一定預測價值。
목적：연구원발성고혈압（EH）환자혈청광억소C（Cys C）여심장중구적상관성。방법납입수축공능정상（LVEF＞50%）적EH환자200례위시험조，납입정상체검자50례위대조조，대상술대상진행혈청CysC농도검측병행초성심동도검사，측량좌심방내경（LAD）、좌심실서장말기내경（LVDD）、실간격후도（IVS）、좌심실후벽후도（LVPW），병계산좌심실중량지수（LVMI）；대조조상술지표정상，시험조근거혈청CysC중위수농도（1.05 mg/L）분위CysC승고조（98례）급CysC정상조（102례）。결과시험조교대조조혈청CysC농도명현승고（P＜0.05）。CysC승고조적LAD、LVDD、IVS、LVPW、LVMI교CysC정상조현저증고（P＜0.05）。CysC함량여LAD、LVDD、IVS、LVPW、LVMI정정상관관계（상관계수분별위0.422、0.381、0.367、0.256、0.350，P＜0.05），혈청CysC농도시심장중구적현저영향인소。결론원발성고혈압환자혈청CysC농도여심장중구상관，대고혈압심장중구적정도급예후판단유일정예측개치。
Objective To study the correlation between the level of serum Cystatin C and cardiac remodeling in patients with essential hypertension(EH). Methods Two hundred patients diagnosed as EH with normal heart function and 50 normal controls who had measurement of CysC were enrolled in this study.Then the group of patients with essential hypertension, whose LAD, LVDD, IVS, LVPW were measured using echocardiography and LVMI was evaluated, were divided into two groups based on the serum Cystatin C level, Results The serum CysC level in patients with hypertension was higher than that in control group(P<0.05). With the increase of serum CysC levels, the mesurement of LAD, LVDD, IVS, LVPW increased.Multivariable stepwise regression analysis showed that CysC had significant correlation with LAD, LVDD, IVS, LVPW. With the increase of serum levels of CysC, the cardiac remodeling was more obvious. Conclusion The serum level of CysC was positively related with cadiac remodeling, the concentration of serum CysC may be a promising predictor of cardiac remodeling and prognosis in EH.
