CAJ | 학술논문

目的应用厄贝沙坦联合法莫替丁治疗慢性充血性心力衰竭（CHF）患者，观察与单独应用厄贝沙坦的疗效比较。方法将120例慢性心力衰竭患者（NYHA分级为Ⅱ～Ⅳ级）随机分为对照组以及试验组。对照组在控制病因、休息和控制水钠摄入的基础上给予厄贝沙坦（75～150 mg/d），试验组在对照组基础上加用法莫替丁（20 mg，2次/d）。随访60 d，根据患者病情变化调整药量，评估病患临床表现变化，心率、血压、运动耐量（6 min步行距离）、超声心动图相关指标（LVED、LVES、LVEF）以及血清中脑尿钠肽（BNP）的水平，对疗效进行评价。结果两组治疗前各指标比较差异无统计学意义。60 d后，试验组较之对照组，心功能分级明显提升，心率、血压以及运动耐量明显改善，超声心动图相关指标以及血清 BNP 水平明显恢复，差异存在统计学意义（P＜0.01）。结论法莫替丁联合厄贝沙坦治疗充血性心力衰竭比单独应用厄贝沙坦的疗效更加明显。
목적응용액패사탄연합법막체정치료만성충혈성심력쇠갈（CHF）환자，관찰여단독응용액패사탄적료효비교。방법장120례만성심력쇠갈환자（NYHA분급위Ⅱ～Ⅳ급）수궤분위대조조이급시험조。대조조재공제병인、휴식화공제수납섭입적기출상급여액패사탄（75～150 mg/d），시험조재대조조기출상가용법막체정（20 mg，2차/d）。수방60 d，근거환자병정변화조정약량，평고병환림상표현변화，심솔、혈압、운동내량（6 min보행거리）、초성심동도상관지표（LVED、LVES、LVEF）이급혈청중뇌뇨납태（BNP）적수평，대료효진행평개。결과량조치료전각지표비교차이무통계학의의。60 d후，시험조교지대조조，심공능분급명현제승，심솔、혈압이급운동내량명현개선，초성심동도상관지표이급혈청 BNP 수평명현회복，차이존재통계학의의（P＜0.01）。결론법막체정연합액패사탄치료충혈성심력쇠갈비단독응용액패사탄적료효경가명현。
Objective To observe the protective effect of Irbesartan along with Famotidine on treating the chronic heart failure patients. Methods 120 congestive heart failure (CHF) patients (cardiac function defined ranging from class Ⅱ to class Ⅳ by NYHA classification) were randomly subjected into two groups: Control group and Experiment group. The routine treatments were given to both groups. The control was given the Irbesartan 75-150 mg per day. Besides Irbesartan the experiment group was given the Famotidine 20 mg per day. Patients were followed up for 60 days,and the clinical manifestation, HR, BP, exercise tolerance, and Doppler UCG as well as BNP level were measured. Results There were no differences between the two groups before the treatment.After 60 days follow up, the clinical manifestation, HR, BP, exercise tolerance, and Doppler UCG as well as BNP level were significantly ameliorated by given Irbesartan along with Famotidine compared with Irbesartan alone. Conclusion Irbesartan given along with Famotidine could ameliorate the cardiac function better than single treatment.