CAJ | 학술논문

三叉神经主要司职牙体和口颌面部的本体感觉传导，其膜表面有较高水平的瞬时受体电位香草酸亚型（TRPV）1表达。TRPV1属于瞬时受体电位离子通道家族成员之一，具有阳离子选择性，一经激活，可在三叉神经节和背根神经节介导疼痛及其传导。神经肽、缓激肽、前列腺素、神经生长因子和5-羟色胺等可以通过TRPV1通道直接刺激神经的疼痛感受器，引起疼痛敏感。温度和酸碱度亦可能引起相似的TRPV1通道结构改变。TRPV1的调控机制复杂并表现在诸多层面上，从基因转录、翻译和修饰到受体亚型的形成等，这些机制一方面维持TRPV1通道正常的生理功能，一方面也是造成其通道功能异常进而引起疼痛的根源。本文就TRPV1介导疼痛的机制和TRPV1的分子调控机制等研究进展作一综述。
삼차신경주요사직아체화구합면부적본체감각전도，기막표면유교고수평적순시수체전위향초산아형（TRPV）1표체。TRPV1속우순시수체전위리자통도가족성원지일，구유양리자선택성，일경격활，가재삼차신경절화배근신경절개도동통급기전도。신경태、완격태、전렬선소、신경생장인자화5-간색알등가이통과TRPV1통도직접자격신경적동통감수기，인기동통민감。온도화산감도역가능인기상사적TRPV1통도결구개변。TRPV1적조공궤제복잡병표현재제다층면상，종기인전록、번역화수식도수체아형적형성등，저사궤제일방면유지TRPV1통도정상적생리공능，일방면야시조성기통도공능이상진이인기동통적근원。본문취TRPV1개도동통적궤제화TRPV1적분자조공궤제등연구진전작일종술。
Trigeminal nerve as mixed nerve mainly conducts the feeling coming from tooth and maxillofacial region. Transient receptor potential vanilloid(TRPV) 1 is highly expressed on the membrane of trigeminal ganglion. TRPV1 is one of the members of transient receptor potential(TRP) family, which is a kind of cation selective channel contributing to the conduction of pain based on trigeminal ganglion, dorsal root ganglion and so on. Nociception on nerve can be directly stimulated by neuropeptide, bradykinin, prostaglandin, nerve growth factor, 5-hydroxytryptamine, as well as temperature and pH, through TRPV1 as a result of pain. The regulatory mechanisms of TRPV1 are various and complex as on the processes like gene transcription, translation and expression as well as the formation of the receptor subtype. These mechanisms have effects on maintaining the normal physiological functions, also are the possible causes of dysfunction of TRPV1 leading to pain rising. In this review, the pain development and regulatory mechanisms of TRPV1 are mainly reviewed.