CAJ | 학술논문

高速泳动族蛋白盒（HMGB）1是一种高度保守的DNA结合蛋白，与基因转录以及染色体的稳定、重组和修复有关。HMGB1是一种细胞外重要的炎症因子，通过主动和被动释放等途径释放到细胞外，介导炎症的发展过程。在慢性牙周炎、侵袭性牙周炎和种植体周围炎病变的牙周组织中，HMGB1的表达远高于健康的牙周组织。HMGB1可以使牙周膜成纤维细胞核因子-κB受体活化因子配体与骨保护蛋白间的比值升高，从而有助于破骨细胞生成，促进牙槽骨的破坏吸收。白细胞介素与牙周炎的炎性反应密切相关，HMGB1可通过促进牙周膜成纤维细胞产生白细胞介素等炎症因子，促进牙周病的发展和牙槽骨吸收。本文就HMGB1在细胞核内的作用、HMGB1的释放途径、HMGB1的细胞外作用、HMGB1在牙周病中的作用等研究进展作一综述。
고속영동족단백합（HMGB）1시일충고도보수적DNA결합단백，여기인전록이급염색체적은정、중조화수복유관。HMGB1시일충세포외중요적염증인자，통과주동화피동석방등도경석방도세포외，개도염증적발전과정。재만성아주염、침습성아주염화충식체주위염병변적아주조직중，HMGB1적표체원고우건강적아주조직。HMGB1가이사아주막성섬유세포핵인자-κB수체활화인자배체여골보호단백간적비치승고，종이유조우파골세포생성，촉진아조골적파배흡수。백세포개소여아주염적염성반응밀절상관，HMGB1가통과촉진아주막성섬유세포산생백세포개소등염증인자，촉진아주병적발전화아조골흡수。본문취HMGB1재세포핵내적작용、HMGB1적석방도경、HMGB1적세포외작용、HMGB1재아주병중적작용등연구진전작일종술。
High-mobility group protein box(HMGB) 1 protein is a highly conserved nuclear DNA-binding protein that has an important function in gene transcription and DNA recombination and repair. HMGB1 contributes in the inflammation process when secreted in the extracellular milieu. HMGB1 highly expressed in the periodontal tissue of periodontitis, aggressive periodontitis, and peri-implantitis. HMGB1 can increase the ratio of the receptor activator of nuclear factor-κB ligand and osteoprotegerin, contribute to osteoclast formation, and promote destruction of the alveolar bone. Interleukin is closely related to the inflammatory reaction of periodontitis. HMGB1 can promote production of interleukin and other inflammatory factors by periodontal ligament fibroblasts and accelerate the development of periodontal disease and alveolar bone resorption. This review will introduce the functions of HMGB1 in the nucleus and outside the cell, the release pathways of HMGB1, and the role of HMGB1 in the development of periodontal disease.