CAJ | 학술논문

目的：探索替吉奥联合奥沙利铂化疗对晚期胃癌TAM、CEA、CA72-4的影响及其临床意义。方法采用ELISA法对54例胃癌患者化疗前后血清中CEA、CA72-4进行检测；应用生化法对其血清TAM进行检测，并评定不良反应情况。结果2个化疗周期后TAM，CEA，CA72-4水平均降低，较化疗前差异具有统计学意义（ P＜0．05）。化疗有效的病例血清中TAM，CEA及CA72-4水平下降明显，而进展病例血清中TAM，CEA及CA72-4水平不同程度的升高，差异有统计学意义（P＜0．05）。结论 TAM、CEA、CA72-4的联合检测可作为晚期胃癌化疗效果的早期预测指标。
목적：탐색체길오연합오사리박화료대만기위암TAM、CEA、CA72-4적영향급기림상의의。방법채용ELISA법대54례위암환자화료전후혈청중CEA、CA72-4진행검측；응용생화법대기혈청TAM진행검측，병평정불량반응정황。결과2개화료주기후TAM，CEA，CA72-4수평균강저，교화료전차이구유통계학의의（ P＜0．05）。화료유효적병례혈청중TAM，CEA급CA72-4수평하강명현，이진전병례혈청중TAM，CEA급CA72-4수평불동정도적승고，차이유통계학의의（P＜0．05）。결론 TAM、CEA、CA72-4적연합검측가작위만기위암화료효과적조기예측지표。
Objective To explore the effect of tegafur combined with oxaliplatin chemotherapy on TAM ,CEA and CA72-4 of advanced gastric cancer patients and its clinical significance .Methods CEA and CA72-4 in 54 patients with gastric cancer before and after chemotherapy were detected by ELISA;serum TAM of the 54 patients were detected by biochemical methods ,and adverse reactions were analyzed .Results After 2 chemotherapy cycles ,TAM,CEA and CA72-4 levels all dropped ,and the differ-ence was statistically significant(P<0.05);the TAM,CEA and CA72-4 levels of the chemotherapy effective cases decreased sig-nificantly;but the serum TAM ,CEA and CA72-4 levels of advanced cases increased in varying degrees ,the difference was statisti-cally significant(P<0.05).Conclusion Combined detection of TAM,CEA and CA72-4 can be used as an early predictive in-dex of efficacy of advanced gastric cancer patients treated with chemotherapy .