CAJ | 학술논문

胃泌酸调节素（oxyntomodulin，OXM）是一种天然肽类激素，是胰高血糖素原基因在胃肠道和中枢神经系统转录后加工的产物之一。新近研究发现， OXM 通过同时激活胰高血糖素样肽-1（glucagon-like peptide-1，GLP-1）受体和胰高血糖素受体，发挥调控食欲、增加能量消耗、促进胰岛素释放及β细胞保护等重要生理作用，体现出良好的体重干预和改善糖耐量效果。本文对 OXM 的来源、结构、代谢等分别作简要介绍，重点综述OXM在干预体重和糖代谢方面的作用及其机制的研究概况，并讨论OXM及OXM类似物在肥胖和肥胖合并糖耐量异常/2型糖尿病的应用前景。
위비산조절소（oxyntomodulin，OXM）시일충천연태류격소，시이고혈당소원기인재위장도화중추신경계통전록후가공적산물지일。신근연구발현， OXM 통과동시격활이고혈당소양태-1（glucagon-like peptide-1，GLP-1）수체화이고혈당소수체，발휘조공식욕、증가능량소모、촉진이도소석방급β세포보호등중요생리작용，체현출량호적체중간예화개선당내량효과。본문대 OXM 적래원、결구、대사등분별작간요개소，중점종술OXM재간예체중화당대사방면적작용급기궤제적연구개황，병토론OXM급OXM유사물재비반화비반합병당내량이상/2형당뇨병적응용전경。
Oxyntomodulin (OXM) is a natural peptide hormone and it is one of the product of the posttranslational processing of proglucagon gene in the gastrointestinal tract and central nervous system. Recently, OXM has been found to play an important physiological role in regulating appetite, increasing energy expenditure, stimulating the release of insulin and protecting beta-cell via activating the GLP-1 receptor and the glucagon receptor simultaneously, and exhibits a good effect of weight intervention and glucose tolerance improvement. This review introduces the discovery, structure and metabolism of OXM, especially its effect on body weight and glucose metabolism and the related mechanism, and discuss the application prospect of OXM and its analogues in obesity patients with or without impaired glucose tolerance or type 2 diabetes mellitus.