中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
24期
11767-11770
,共4页
糖尿病,2型%脑缺血%HSP70热休克蛋白质类
糖尿病,2型%腦缺血%HSP70熱休剋蛋白質類
당뇨병,2형%뇌결혈%HSP70열휴극단백질류
Diabetes mellitus,type 2%Brain ischemia%HSP70 heat-shock proteins
2型糖尿病合并脑缺血疾病越来越受关注,它是2型糖尿病患者致死、致残的主要原因之一,严重影响患者的生存和生活质量。缺血性脑梗死的发生与炎症反应、细胞凋亡等有关。近年来,与炎症和细胞凋亡相关的热休克70(HSP70)家族因具有广泛的生物学功能而成为生命科学研究中的热点,并且其在脑缺血中的神经保护作用的研究越来越受到重视,现就HSP70与糖尿病合并脑缺血性疾病的关系作一综述。
2型糖尿病閤併腦缺血疾病越來越受關註,它是2型糖尿病患者緻死、緻殘的主要原因之一,嚴重影響患者的生存和生活質量。缺血性腦梗死的髮生與炎癥反應、細胞凋亡等有關。近年來,與炎癥和細胞凋亡相關的熱休剋70(HSP70)傢族因具有廣汎的生物學功能而成為生命科學研究中的熱點,併且其在腦缺血中的神經保護作用的研究越來越受到重視,現就HSP70與糖尿病閤併腦缺血性疾病的關繫作一綜述。
2형당뇨병합병뇌결혈질병월래월수관주,타시2형당뇨병환자치사、치잔적주요원인지일,엄중영향환자적생존화생활질량。결혈성뇌경사적발생여염증반응、세포조망등유관。근년래,여염증화세포조망상관적열휴극70(HSP70)가족인구유엄범적생물학공능이성위생명과학연구중적열점,병차기재뇌결혈중적신경보호작용적연구월래월수도중시,현취HSP70여당뇨병합병뇌결혈성질병적관계작일종술。
Type 2 diabetes mellitus with cerebral ischemic disease have been growing concerned, it is one of the main reasons of death, disability in type 2 diabetes mellitus, affecting patients' survival and quality of life seriously. The occurrence of cerebral infarction is in related with inflammation and apoptosis. In recent years, inflammation and apoptosis-related heat shock 70 (HSP70) family has become a hot spot in life science research because of its extensive biological functions, and the research about its neuroprotections in cerebral ischemia have received more attention, Now we have a review on the relationship of HSP70 and diabetic patients with cerebral ischemic disease .