中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
24期
11759-11762
,共4页
超长链脂肪酸延伸酶6%胰岛素抵抗%非酒精性脂肪肝%代谢性疾病
超長鏈脂肪痠延伸酶6%胰島素牴抗%非酒精性脂肪肝%代謝性疾病
초장련지방산연신매6%이도소저항%비주정성지방간%대사성질병
Elongation of very long chain fatty acids protein 6%Insulin resistance%Nonalcoholic steatohepatitis%Metabolic disease
代谢综合征(MS)与冠心病、高血压、脑卒中、痛风、非酒精性脂肪肝(NASH)等疾病群密切相关,胰岛素抵抗(IR)是MS的中心环节。超长链脂肪酸延伸酶6(ELOVL6)是ELOVL家族的第6个成员,广泛分布于具有内质网结构的组织细胞中,主要参与C12-16饱和与不饱和脂肪酸的合成,ELOVL6可通过调节细胞内脂质成分,从而影响胰岛素受体磷酸化,调节部分炎性体,炎性因子活性和炎性信号通路蛋白磷酸化水平,在机体能量代谢平衡,IR、NASH及动脉粥样硬化等疾病的发病中发挥着重要作用。
代謝綜閤徵(MS)與冠心病、高血壓、腦卒中、痛風、非酒精性脂肪肝(NASH)等疾病群密切相關,胰島素牴抗(IR)是MS的中心環節。超長鏈脂肪痠延伸酶6(ELOVL6)是ELOVL傢族的第6箇成員,廣汎分佈于具有內質網結構的組織細胞中,主要參與C12-16飽和與不飽和脂肪痠的閤成,ELOVL6可通過調節細胞內脂質成分,從而影響胰島素受體燐痠化,調節部分炎性體,炎性因子活性和炎性信號通路蛋白燐痠化水平,在機體能量代謝平衡,IR、NASH及動脈粥樣硬化等疾病的髮病中髮揮著重要作用。
대사종합정(MS)여관심병、고혈압、뇌졸중、통풍、비주정성지방간(NASH)등질병군밀절상관,이도소저항(IR)시MS적중심배절。초장련지방산연신매6(ELOVL6)시ELOVL가족적제6개성원,엄범분포우구유내질망결구적조직세포중,주요삼여C12-16포화여불포화지방산적합성,ELOVL6가통과조절세포내지질성분,종이영향이도소수체린산화,조절부분염성체,염성인자활성화염성신호통로단백린산화수평,재궤체능량대사평형,IR、NASH급동맥죽양경화등질병적발병중발휘착중요작용。
Metabolic syndrome(MS) has a close relationship with coronary disease, hypertension, apoplexy, primary gouty arthritis and nonalcoholic steatohepatitis (NASH), insulin resistance (IR) plays a crucial role in the occer and developmengt of MS. Elongation of very long chain fatty acids protein 6 is the sixth member of the ELOVL family, and expresses in all cells which has the Endoplasmic reticulum structure, mainly elongates C14-16 aliphatic acid. ELOVL6 has an important role in energy metabolism. through regulate the composition of fatty acid in cells, affect some inflammasome and inflammatory factor activity sequentially, and then influence the occurrence and development of IR, NASH, atherosclerosis and other metabolic disease.