CAJ | 학술논문

目的：探讨冠心病患者冠状动脉造影病变程度与血清超敏C反应蛋白(hs-CRP)水平的关系。方法选择2010年3月～2013年2月本院心内科收治的临床可疑冠心病患者282例，同时进行冠状动脉造影检查及超敏C反应蛋白的测定，并进行比较分析。结果冠心病组血清hs-CRP水平显著高于对照组（P＜0.05）；冠状动脉病变支数各组（由单支到多支）hs-CRP水平呈递增趋势，各组差异存在统计学意义（P＜0.05）；冠脉狭窄各组血清hs-CRP水平较对照组明显增高（P＜0.05），且随冠状动脉狭窄程度加重，血清hs-CRP增高明显，各组间比较均有显著性差异（P＜0.05）；Spearman秩相关分析表明，hs-CRP与冠状动脉病变支数和狭窄程度均呈正相关（P＜0.05），相关系数分别为0.175，0.173。结论hs-CRP水平与冠心病患者冠状动脉病变程度有相关性,随着冠状动脉病变程度加重，hs-CRP水平显著增高。
목적：탐토관심병환자관상동맥조영병변정도여혈청초민C반응단백(hs-CRP)수평적관계。방법선택2010년3월～2013년2월본원심내과수치적림상가의관심병환자282례，동시진행관상동맥조영검사급초민C반응단백적측정，병진행비교분석。결과관심병조혈청hs-CRP수평현저고우대조조（P＜0.05）；관상동맥병변지수각조（유단지도다지）hs-CRP수평정체증추세，각조차이존재통계학의의（P＜0.05）；관맥협착각조혈청hs-CRP수평교대조조명현증고（P＜0.05），차수관상동맥협착정도가중，혈청hs-CRP증고명현，각조간비교균유현저성차이（P＜0.05）；Spearman질상관분석표명，hs-CRP여관상동맥병변지수화협착정도균정정상관（P＜0.05），상관계수분별위0.175，0.173。결론hs-CRP수평여관심병환자관상동맥병변정도유상관성,수착관상동맥병변정도가중，hs-CRP수평현저증고。
Objective To investigate the relationship between the intensity of coronary artery lesions and the level of highsensitivity C-reactive protein (hs-CRP).Methods A total of 282 suspective patients were performed coronary artery angiography.The levels of hs-CRP and the intensity of coronary artery disorder were recorded.Results The level of hs-CRP in CHD group was markedly higher than that in normal group(P<0.05).The levels of hs-CRP in 2 branch and 3 branch lesions subgroup were markedly higher than that in single branch subgroup(P<0.05).The levels of hs-CRP increased with index of coronary arterial lesion(P<0.05).The levels hs-CRP levels were positively correlated with the extent and index of coronary arterial lesion(P<0.05). Conclusion Hs-CRP increase along with aggravation in the severity of coronary lesion.