CAJ | 학술논문

目的：观察子宫螺旋动脉血流动力学参数与孕妇血清中胎盘生长因子（PLGF）含量，两者结合分析子痫前期的严重程度。方法对30例初诊子痫前期孕妇及154名健康孕妇，通过彩色多普勒超声技术（CDFI）检测子宫螺旋动脉血流动力学参数：搏动指数（PI）值、阻力指数（RI）值、收缩期峰值流速与舒张末期血流速度之比值（S/D）。使用酶联免疫吸附试验（ELISA）法测定孕妇血清中PLGF的含量。结果（1）子痫前期组的PI值、RI值、S/D值较对照组有所增高，差异有统计学意义（P＜0.01）。子痫前期重度组较轻度组的值增高，差异有统计学意义（P＜0.001）。（2）子痫前期组的血清PLGF含量较对照组降低，差异有统计学意义（P＜0.001），子痫前期重度组低于轻度组，差异有统计学意义（P＜0.001）。（3）子痫前期血清PLGF分别与PI（r=-0.55，P＜0.05）、RI（r=-0.58，P＜0.05）、S/D（r=-0.62，P＜0.05），呈显著负相关。结论（1）彩色多普勒超声技术检测子宫螺旋动脉血流、孕妇血清PLGF含量都与子痫前期严重程度相关。（2）子宫螺旋动脉血流动力学参数与子痫前期孕妇血清PLGF表达之间呈显著负相关。
목적：관찰자궁라선동맥혈류동역학삼수여잉부혈청중태반생장인자（PLGF）함량，량자결합분석자간전기적엄중정도。방법대30례초진자간전기잉부급154명건강잉부，통과채색다보륵초성기술（CDFI）검측자궁라선동맥혈류동역학삼수：박동지수（PI）치、조력지수（RI）치、수축기봉치류속여서장말기혈류속도지비치（S/D）。사용매련면역흡부시험（ELISA）법측정잉부혈청중PLGF적함량。결과（1）자간전기조적PI치、RI치、S/D치교대조조유소증고，차이유통계학의의（P＜0.01）。자간전기중도조교경도조적치증고，차이유통계학의의（P＜0.001）。（2）자간전기조적혈청PLGF함량교대조조강저，차이유통계학의의（P＜0.001），자간전기중도조저우경도조，차이유통계학의의（P＜0.001）。（3）자간전기혈청PLGF분별여PI（r=-0.55，P＜0.05）、RI（r=-0.58，P＜0.05）、S/D（r=-0.62，P＜0.05），정현저부상관。결론（1）채색다보륵초성기술검측자궁라선동맥혈류、잉부혈청PLGF함량도여자간전기엄중정도상관。（2）자궁라선동맥혈류동역학삼수여자간전기잉부혈청PLGF표체지간정현저부상관。
Objective To analyze the correlation between altered hemodynamics of uterine spiral artery and severity of pre-eclampsia during pregnancy by color Doppler ultrasound detection of uterine spiral artery and test of serum avscular placenta growth factor(PLGF). Methods Before pharmacotherapy, the uterine spiral artery was measured with color Doppler ultrasound in 30 cases of pre-eclampsia complicating pregnancy and 154 cases of normal pregnancy. The results were recorded and compared between the two groups. ELISA was used for detecting serum PLGF in all subjects. Results (1)Of the uterine spiral artery hemodynamic parameters, PI, RI and S/D were higher in pre-eclampsia group than in normal group (P < 0.01). These hemodynamic parameters were higher in patients with severe pre-eclampsia than in mild cases (P<0.001).(2)The contents of serum PLGF was lower in pre-eclampsia group than in normal group(P<0.001), and in severe pre-eclampsia group and in mild cases(P<0.01).(3)Serum PLGF level was negatively correlated with parameters of uterine spiral artery hemodynamics [PI (r=-0.55, P < 0.05), RI (r=-0.58, P < 0.05) and S/D(r=-0.62, P<0.05)] in pre-eclamptic pregnancy (P<0.01). Conclusion (1)Color Doppler ultrasound detection of uterine spiral artery flow and detect the amount of PLGF may be useful to predict severity of pre-eclampsia during pregnancy. (2)The hemodynamic parameters of uterine spiral artery correlates negatively with expression of serum PLGF in pre-eclamptic pregnancy.