CAJ | 학술논문

目的：分析研究使用近红外光谱测定技术在窒息新生儿脑血流及氧合代谢变化测定的应用效果。方法选择2013年3月~2013年10月我院妇产科内出生的足月窒息新生儿45例作为本次实验的研究对象，根据患者的窒息严重程度分为轻度窒息、重度窒息两组。其中实验组23例，包括轻度、重度窒息为11、12例，使用NIRS检测脑血流；对照组22例，包括轻、重度窒息各11例，使用头颅CT检测。观察比较轻重度患者脑血流及氧合代谢及两种方法的检查结果。结果轻重度窒息新生儿脑血容量tHb[轻度窒息出生后12h为（0.16±0.07）μmol/L、24h为（1.82±0.52）μmol/L、72h为（3.23±0.61）μmol/L；重度为（0.63±0.12）μm o l/L、（3.31±0.56）μmol/L、（2.61±1.65）μmol/L]和脑组织灌注HbD[轻度为：（2.11±0.56）μmol/L、（3.38±0.44）μmol/L、（4.45±0.97）μmol/L；重度为（4.27±1.02）μmol/L、（4.94±0.71）μmol/L、（3.57±1.34）μmol/L]比较差异有统计学意义（P＜0.05）。结论使用近红外光谱测定技术在窒息新生儿脑血流及氧合代谢变化中具有较好的应用效果，可以更好地判断新生儿的窒息严重程度，是一种较好的方法。
목적：분석연구사용근홍외광보측정기술재질식신생인뇌혈류급양합대사변화측정적응용효과。방법선택2013년3월~2013년10월아원부산과내출생적족월질식신생인45례작위본차실험적연구대상，근거환자적질식엄중정도분위경도질식、중도질식량조。기중실험조23례，포괄경도、중도질식위11、12례，사용NIRS검측뇌혈류；대조조22례，포괄경、중도질식각11례，사용두로CT검측。관찰비교경중도환자뇌혈류급양합대사급량충방법적검사결과。결과경중도질식신생인뇌혈용량tHb[경도질식출생후12h위（0.16±0.07）μmol/L、24h위（1.82±0.52）μmol/L、72h위（3.23±0.61）μmol/L；중도위（0.63±0.12）μm o l/L、（3.31±0.56）μmol/L、（2.61±1.65）μmol/L]화뇌조직관주HbD[경도위：（2.11±0.56）μmol/L、（3.38±0.44）μmol/L、（4.45±0.97）μmol/L；중도위（4.27±1.02）μmol/L、（4.94±0.71）μmol/L、（3.57±1.34）μmol/L]비교차이유통계학의의（P＜0.05）。결론사용근홍외광보측정기술재질식신생인뇌혈류급양합대사변화중구유교호적응용효과，가이경호지판단신생인적질식엄중정도，시일충교호적방법。
Objective To analyze and study the application effect of determination of near infrared spectroscopy in asphyxia newborn cerebral blood flow and oxygen metabolism changes. Methods 45 full-term asphyxia newborns who were born in the obstetrics and gynecology department of our hospital from March 2013 to October 2013 were selected as the research objects, which were divided into the mild asphyxia group and severe asphyxia group according to the patient’s severity of asphyxia. Of which 23 patients in the experimental group which included 11 mild asphyxia patients and 12 severe asphyxia patients were given the cerebral blood flow detection by using NIRS;While 22 cases in the control group which included 11 mild asphyxia patients and 11 severe asphyxia patients were given the cerebral blood flow detection by using the cerebral CT scan. The cerebral blood flow and oxygen metabolism examination results of mild, severe asphyxia patients by using the two methods were observed and compared. Results The cerebral blood volume tHb in the mild asphyxia newborns at 12h, 24h, 72h after birth was(0.16±0.07)μmol/L,(1.82±0.52)μmol/L, (3.23±0.61)μmol/L respectively, while that in the severe asphyxia newborns was (0.63±0.12)μmol/L,(3.31±0.56)μmol/L,(2.61±1.65)μmol/L respectively; The cerebral tissue perfusion HbD in the mild asphyxia newborns at 12h, 24h, 72h after birth was(2.11±0.56)μmol/L,(3.38±0.44)μmol/L,(4.45±0.97)μmol/L respectively, while that in the severe asphyxia newborns was (4.27±1.02)μmol/L,(4.94±0.71)μmol/L,(3.57±1.34)μmol/L respectively. The differences were statistically significant in the cerebral blood volume tHb and cerebral tissue perfusion HbD at 12h, 24h, 72h after birth between the mild and severe asphyxia newborns(P < 0.05). Conclusion Determination of near infrared spectroscopy has better effect in the application of asphyxia newborn cerebral blood flow and oxygen metabolism changes, can better judge the severity of asphyxia newborn, and is a kind of better method.