CAJ | 학술논문

目的：检测静脉血栓栓塞症（VTE）患者血清中抗凝血酶（AT3）、蛋白C（PC）、蛋白S（PS）水平，分析其与VTE的关系。方法回顾性分析251例VTE患者性别、年龄特点及血清中AT3、PC、PS的水平，并与60例正常人血样进行对比。结果251例VTE患者中，男94例，女157例，男︰女=1.11︰1.4，中位年龄43（5~81）岁。AT3、PC、PS三者均有不同程度降低，其中AT3占15.14%（38例），PC占10.36%（26例）， PS占20.3%（51例）。结论血浆AT3、PC、PS缺陷是促发VTE的重要原因，检测其水平变化对静脉血栓栓塞症的预防、诊断及治疗有指导意义。
목적：검측정맥혈전전새증（VTE）환자혈청중항응혈매（AT3）、단백C（PC）、단백S（PS）수평，분석기여VTE적관계。방법회고성분석251례VTE환자성별、년령특점급혈청중AT3、PC、PS적수평，병여60례정상인혈양진행대비。결과251례VTE환자중，남94례，녀157례，남︰녀=1.11︰1.4，중위년령43（5~81）세。AT3、PC、PS삼자균유불동정도강저，기중AT3점15.14%（38례），PC점10.36%（26례）， PS점20.3%（51례）。결론혈장AT3、PC、PS결함시촉발VTE적중요원인，검측기수평변화대정맥혈전전새증적예방、진단급치료유지도의의。
Objective To explore the relationship between AT3, PC, PS and VTE by detecting the level of antithrombinⅢ(AT3), protein C(PC), protein S(PS) in the serum of patients with venous thromboembolism. Methods The clinical data in 251 patients with VTE were analyzed retrospectively, with 60 cases of normal blood samples were compared, characteristics of gender and age, as well as the levels of AT3, PC, PS in serum were included. Results In total of 251 patients with VTE: 94 male and 157 female, male: female = 1.11:1.4, median age 43 (5-81) years. AT3, PC and PS were reduced to varying degrees, AT3 accounted for 15.14%(38 cases), PC accounted for 10.36%(26 cases), PS accounted for 20.3%(51 cases). Conclusion The deficiency of AT3, PC, PS plays a very important role in triggering VTE, therefore, detecting the levels of these three natural anticoagulants are of significant, especially for the prevention, diagnosis and treatment of venous thromboembolism.