CAJ | 학술논문

目的：对比氯氮平与奥氮平在治疗阿尔茨海默病中对精神症状的疗效与不良反应观察。方法：对23例氯氮平与23例奥氮平治疗有精神病性症状的阿尔茨海默病患者，在治疗0、2、4、8周分别用简明精神病评定量表（BPRS）评定，治疗中用症状量表（TESS）评定，对比两组疗效及不良反应观察。结果：治疗2周时，两组患者BPRS评分均较治疗前显著降低（P均<0.05)，两组的BPRS评分在不同的治疗时间差异无显著性（P<0.05）。2、4、8周时奥氮平组的TESS评分明显低于氯氮平组，两组存在显著差异（P<0.05)。结论：氯氮平与奥氮平在治疗阿尔茨海默病的精神症状疗效基本相似，但奥氮平的不良反应明显低于氯氮平。
목적：대비록담평여오담평재치료아이자해묵병중대정신증상적료효여불량반응관찰。방법：대23례록담평여23례오담평치료유정신병성증상적아이자해묵병환자，재치료0、2、4、8주분별용간명정신병평정량표（BPRS）평정，치료중용증상량표（TESS）평정，대비량조료효급불량반응관찰。결과：치료2주시，량조환자BPRS평분균교치료전현저강저（P균<0.05)，량조적BPRS평분재불동적치료시간차이무현저성（P<0.05）。2、4、8주시오담평조적TESS평분명현저우록담평조，량조존재현저차이（P<0.05)。결론：록담평여오담평재치료아이자해묵병적정신증상료효기본상사，단오담평적불량반응명현저우록담평。
objective: to compare the clozapine and olanzapine in the treatment of alzheimer's disease to mental symptom curative effect and adverse reactions to observe. Methods:23 cases of 23 cases of clozapine and olanzapine in treatment of psychotic symptoms of alzheimer's patients, in the treatment of 0, 2, 4, 8 weeks, respectively, with the brief psychiatric rating scale (BPRS), treatment with symptoms scale (TESS), compared two groups of curative effect and adverse reaction of observation. Results: two weeks, two groups of patients with BPRS scores were significantly lower than before treatment (P < 0.05), two groups of BPRS score there was no significant difference in different treatment time (P < 0.05). At 2, 4, 8 weeks TESS scores of olanzapine group was obviously lower than clozapine group, significant differences in the two groups (P < 0.05). Conclusion: clozapine and olanzapine in the treatment of alzheimer's disease is similar mental symptoms curative effect, adverse reaction of olanzapine significantly lower than clozapine.