CAJ | 학술논문

目的：观察大蒜多糖对东莨菪碱所导致小鼠学习、记忆功能障碍的作用。方法采用小鼠皮下注射东莨菪碱制作学习记忆障碍模型，然后灌胃大蒜多糖进行干预，通过行为学实验（跳台实验）观察大蒜多糖对学习记忆的影响。结果模型组小鼠在3min内跳台错误次数明显高于正常对照组，大蒜多糖组小鼠错误次数显著低于模型组；模型组小鼠触电潜伏期显著缩短，5min错误次数明显增加，大蒜多糖组小鼠触电潜伏期较模型组明显延长，5min错误次数显著减少。结论大蒜多糖可改善东莨菪碱所致小鼠学习记忆障碍。
목적：관찰대산다당대동랑탕감소도치소서학습、기억공능장애적작용。방법채용소서피하주사동랑탕감제작학습기억장애모형，연후관위대산다당진행간예，통과행위학실험（도태실험）관찰대산다당대학습기억적영향。결과모형조소서재3min내도태착오차수명현고우정상대조조，대산다당조소서착오차수현저저우모형조；모형조소서촉전잠복기현저축단，5min착오차수명현증가，대산다당조소서촉전잠복기교모형조명현연장，5min착오차수현저감소。결론대산다당가개선동랑탕감소치소서학습기억장애。
Objective To explore the effect of garlic polysaccharide on scopolamine induced learning and memory impairment in mice .Methods Mice model of learning and memory disorder were produced by sco-polamine .The effect of garlic polysaccharide on learning and memory were tested by step-down test .Results The jumping error number within 3 min of model group was higher than that of normal control group and the jumping error number within 3min of garlic polysaccharide groups were lower than that of model group .The error times of garlic polysaccharide groups were less than those in model group in five minutes .Conclusion Garlic polysaccharide may improve learning and memory defict induced by scopolamine .