CAJ | 학술논문

目的：观察南五加皮煎剂对小白鼠四氯化碳（ CCl4）化学性肝损伤的保护作用。方法将60只健康的小白鼠均分为南五加皮煎剂小、中、大剂量组，正常组及模型组；采用注射CCl4建立小白鼠急性化学性肝损伤模型，通过测定各组动物血浆丙氨酸氨基转移酶（ ALT）活性，丙二醛（ MDA）含量及肝脏系数、肝糖原含量和观察肝脏组织病理学变化，以评价肝脏损伤程度和药物的保护作用。结果南五加皮煎剂各剂量组小白鼠血浆ALT活性、MDA含量及肝脏系数均降低，肝糖原合成增加，肝脏组织病理损伤得到明显改善，且呈明显的量效关系。结论南五加皮煎剂对CCl 4致动物急性肝损伤具有良好的保护作用。
목적：관찰남오가피전제대소백서사록화탄（ CCl4）화학성간손상적보호작용。방법장60지건강적소백서균분위남오가피전제소、중、대제량조，정상조급모형조；채용주사CCl4건립소백서급성화학성간손상모형，통과측정각조동물혈장병안산안기전이매（ ALT）활성，병이철（ MDA）함량급간장계수、간당원함량화관찰간장조직병이학변화，이평개간장손상정도화약물적보호작용。결과남오가피전제각제량조소백서혈장ALT활성、MDA함량급간장계수균강저，간당원합성증가，간장조직병리손상득도명현개선，차정명현적량효관계。결론남오가피전제대CCl 4치동물급성간손상구유량호적보호작용。
Objectvie To investigate the protective effect of Cortex Acanthopanacis Decoction on chemi-cal liver injury induced by carbon tetrachloride ( CCl4 ).Methods 60 healthy mice were divided into small , medium,and high doses of CORTEX ACANTHOPANACIS Decoction groups ,the normal group,and the model group, then acute liver injury models were established by injecting CCl4 .The degree of liver injury and the pro-tective effect of the drug were evaluated by determining plasma alanine aminotransferase ( ALT ) activity ,ma-londialdehyde ( MDA ) content ,liver coefficient ,and liver glycogen amount a,nd by observing liver histopatho -logic changes.Results Plasma ALT activity,MDA content,and liver coefficient in all of the CORTEX ACAN-THOPANACIS Decoction groups were decreased ,while the liver glycogen synthesis were increased .Additional-ly,liver pathological damage were obviously reduced .Moreover,these results showed a distinct dosee-ffect rela -tionship.Conclusion Cortex Acanthopanacis Decoction has a significant protective effect against acute CCl 4-in-duced liver injury .