心脑血管病防治
心腦血管病防治
심뇌혈관병방치
PREVENTION AND TREATMENT OF CARDIO-CEREBRAL-VASCULAR DISEASE
2014年
1期
22-26
,共5页
陈绍稀%吕晶%虞意华%严静
陳紹稀%呂晶%虞意華%嚴靜
진소희%려정%우의화%엄정
甲状腺激素%心力衰竭%低T3综合征%Meta分析
甲狀腺激素%心力衰竭%低T3綜閤徵%Meta分析
갑상선격소%심력쇠갈%저T3종합정%Meta분석
Thyroid hormones%Heart failure%Low T3 syndrome%Meta_Analysis
目的:系统评价甲状腺激素替代治疗心力衰竭伴低T3综合征患者的疗效。方法计算机检索数据库包括Pubmed、Web of Science、COCHRANE LIBRARY、中国生物医学数据库、万方数据库和维普数据库,检索时限从建库至2013年6月,同时追索纳入文章的参考文献。严格按照纳入标准筛选文献、提取资料和评价质量后,应用Review Man-ager 5.2软件对所纳入的研究结果进行Meta分析。结果共纳入11篇RCT文献资料,包括662例心力衰竭伴低T3综合征患者。Meta分析结果显示:与常规治疗组相比,甲状腺素组(甲状腺激素加常规治疗)的左心室射血分数(LVEF)和心输出量(CO )明显增加(MD=5.16,95% CI=3.11~7.21,P<0.01;MD=0.55,95% CI=0.33~0.77,P<0.01),评价心室舒缩功能的E/A值升高和左心室舒张末内径(LVDD )降低(MD=0.22,95% CI=0.09~0.34,P<0.01;MD=-4.14,95% CI=-6.66~-1.61,P<0.01)。结论心力衰竭伴低T3综合征患者在常规治疗基础上加用甲状腺激素可明显提高患者的心脏射血功能及改善心室的舒缩功能。
目的:繫統評價甲狀腺激素替代治療心力衰竭伴低T3綜閤徵患者的療效。方法計算機檢索數據庫包括Pubmed、Web of Science、COCHRANE LIBRARY、中國生物醫學數據庫、萬方數據庫和維普數據庫,檢索時限從建庫至2013年6月,同時追索納入文章的參攷文獻。嚴格按照納入標準篩選文獻、提取資料和評價質量後,應用Review Man-ager 5.2軟件對所納入的研究結果進行Meta分析。結果共納入11篇RCT文獻資料,包括662例心力衰竭伴低T3綜閤徵患者。Meta分析結果顯示:與常規治療組相比,甲狀腺素組(甲狀腺激素加常規治療)的左心室射血分數(LVEF)和心輸齣量(CO )明顯增加(MD=5.16,95% CI=3.11~7.21,P<0.01;MD=0.55,95% CI=0.33~0.77,P<0.01),評價心室舒縮功能的E/A值升高和左心室舒張末內徑(LVDD )降低(MD=0.22,95% CI=0.09~0.34,P<0.01;MD=-4.14,95% CI=-6.66~-1.61,P<0.01)。結論心力衰竭伴低T3綜閤徵患者在常規治療基礎上加用甲狀腺激素可明顯提高患者的心髒射血功能及改善心室的舒縮功能。
목적:계통평개갑상선격소체대치료심력쇠갈반저T3종합정환자적료효。방법계산궤검색수거고포괄Pubmed、Web of Science、COCHRANE LIBRARY、중국생물의학수거고、만방수거고화유보수거고,검색시한종건고지2013년6월,동시추색납입문장적삼고문헌。엄격안조납입표준사선문헌、제취자료화평개질량후,응용Review Man-ager 5.2연건대소납입적연구결과진행Meta분석。결과공납입11편RCT문헌자료,포괄662례심력쇠갈반저T3종합정환자。Meta분석결과현시:여상규치료조상비,갑상선소조(갑상선격소가상규치료)적좌심실사혈분수(LVEF)화심수출량(CO )명현증가(MD=5.16,95% CI=3.11~7.21,P<0.01;MD=0.55,95% CI=0.33~0.77,P<0.01),평개심실서축공능적E/A치승고화좌심실서장말내경(LVDD )강저(MD=0.22,95% CI=0.09~0.34,P<0.01;MD=-4.14,95% CI=-6.66~-1.61,P<0.01)。결론심력쇠갈반저T3종합정환자재상규치료기출상가용갑상선격소가명현제고환자적심장사혈공능급개선심실적서축공능。
Objective To systematically assess the curative effect of thyroxine in patients with heart failure complicating low T 3 syn-drome.Methods Retrieving databases including Pubmed ,Web of Science ,Cochrane Library ,CBM ,WanFang database and VIP database.The retrieval time limited from the foundation of database to June 2013.Meantime ,references of articles were searched.According to the inclusion criterion ,relevant articles were screened.After extracting data ,quality of data was assessed ,and meta_analysis was performed by RevMan 5.2.Results A total of 11 RCTs involving 662 patients were included.The result of meta_analyses showed that ,compared with the control group ,after short_term treatment with thyroxine ,left ventricular ejection fraction (LVEF) and cardiac output (CO ) of the treatment group obviously increased (MD=5.16 ,95% CI=3.11~7.21 , P<0.01;MD=0.55 ,95%CI=0.33~0.7 P<0.01 ).Besides ,the evaluation index of ventricular diastolic function E/A was improved and left ventricular end diastolic diameter (LVDD ) was decreased (MD=0.22 ,95% CI=0.09~0.34 ,P<0.01;MD= -4.14 ,95% CI= -6.66~ -1.61 ,P<0.01 ).Conclusions Thyroxine based on routine treatment can improve the heart ejection function and the ventricular dias-tolic function for patients with heart failure complicating low T 3 syndrome.